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A randomized comparative study of high-dose and low-dose hepatic arterial infusion chemotherapy for intractable, advanced hepatocellular carcinoma.
DC Field | Value | Language |
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dc.contributor.author | Woo, HY | - |
dc.contributor.author | Bae, SH | - |
dc.contributor.author | Park, JY | - |
dc.contributor.author | Han, KH | - |
dc.contributor.author | Chun, HJ | - |
dc.contributor.author | Choi, BG | - |
dc.contributor.author | Im, HU | - |
dc.contributor.author | Choi, JY | - |
dc.contributor.author | Yoon, SK | - |
dc.contributor.author | Cheong, JY | - |
dc.contributor.author | Cho, SW | - |
dc.contributor.author | Jang, BK | - |
dc.contributor.author | Hwang, JS | - |
dc.contributor.author | Kim, SG | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Seo, YS | - |
dc.contributor.author | Yim, HJ | - |
dc.contributor.author | Um, SH | - |
dc.date.accessioned | 2011-05-11T07:02:38Z | - |
dc.date.available | 2011-05-11T07:02:38Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0344-5704 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/2561 | - |
dc.description.abstract | PURPOSE: Hepatic arterial infusion chemotherapy (HAIC) has been reported to be effective in patients with advanced hepatocellular carcinoma (HCC).
METHODS: In this multicenter, prospective, open-labeled, clinical trial, we randomly assigned 68 patients with advanced HCC to receive either low-dose [n = 32, 5-fluorouracil (FU), 170 mg/m(2) and cisplatin, 7 mg/m(2) on days 1-5] or high-dose HAIC (n = 36, 5-FU, 500 mg/m(2) on days 1-3 and cisplatin, 60 mg/m(2) on day 2) every 4 weeks via an implantable port system. RESULTS: A total of 207 cycles of HAIC was given to the 68 patients. Overall, 6 patients (8.8%) achieved a partial response and 21 patients (30.9%) had stable disease. The objective response rate (CR + PR) was significantly improved in the high-dose group compared to the low-dose group (16.7% vs. 0%, P = 0.024). The median time to disease progression and overall survival were slightly prolonged in the high-dose group compared to the low-dose group (median survival, 193 vs. 153 days; P = 0.108; median time to disease progression, 145 vs. 90 days; P = 0.095). Multivariate analysis showed that tumor response to treatment [P = 0.007, RR 2.27 (95% CI, 1.248-4.132)] was the only factor associated with overall survival. All adverse events were tolerable and successfully managed in both treatment groups. CONCLUSIONS: Both HAIC regimens are safe and effective in patients with advanced HCC. High-dose HAIC achieves a better tumor response compared to low-dose HAIC. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols | - |
dc.subject.MESH | Carcinoma, Hepatocellular | - |
dc.subject.MESH | Cisplatin | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorouracil | - |
dc.subject.MESH | Hepatic Artery | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infusions, Intra-Arterial | - |
dc.subject.MESH | Liver Neoplasms | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Survival Rate | - |
dc.title | A randomized comparative study of high-dose and low-dose hepatic arterial infusion chemotherapy for intractable, advanced hepatocellular carcinoma. | - |
dc.type | Article | - |
dc.identifier.pmid | 19763572 | - |
dc.contributor.affiliatedAuthor | 정, 재연 | - |
dc.contributor.affiliatedAuthor | 조, 성원 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s00280-009-1126-2 | - |
dc.citation.title | Cancer chemotherapy and pharmacology | - |
dc.citation.volume | 65 | - |
dc.citation.number | 2 | - |
dc.citation.date | 2010 | - |
dc.citation.startPage | 373 | - |
dc.citation.endPage | 382 | - |
dc.identifier.bibliographicCitation | Cancer chemotherapy and pharmacology, 65(2). : 373-382, 2010 | - |
dc.identifier.eissn | 1432-0843 | - |
dc.relation.journalid | J003445704 | - |
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