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The loss of phenol sulfotransferase 1 in hepatocellular carcinogenesis.

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dc.contributor.authorYeo, M-
dc.contributor.authorNa, YM-
dc.contributor.authorKim, DK-
dc.contributor.authorKim, YB-
dc.contributor.authorWang, HJ-
dc.contributor.authorLee, JA-
dc.contributor.authorCheong, JY-
dc.contributor.authorLee, KJ-
dc.contributor.authorPaik, YK-
dc.contributor.authorCho, SW-
dc.date.accessioned2011-05-11T07:39:00Z-
dc.date.available2011-05-11T07:39:00Z-
dc.date.issued2010-
dc.identifier.issn1615-9853-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2563-
dc.description.abstractBiomarkers for the detection of early hepatocellular carcinoma (HCC) are urgently needed. To identify biomarkers of HCC, we performed a comparative proteomics analysis, based on 2-DE of HCC tissues and surrounding non-tumor tissues. Six xenobiotic enzymes were significantly down-regulated in the HCC tissue. Among these, phenol sulfotransferase (SULT1A1) was confirmed by Western blot analysis in 105 HCC patients. SULT1A1 showed a significant decrease in 98.1% of the HCC tissues, with 88.6% sensitivity and 66.7% specificity for the detection of HCC. Immunohistochemistry for SULT1A1 was performed and compared with glypican-3, which is a well-known marker of HCC. The results showed down-regulation of SULT1A1 and up-regulation of glypican-3 in 52.6 and 71.9% of the HCCs, and the use of both markers improved the sensitivity up to 78.9%. Moreover, SULT1A1 was useful in differentiating early HCC from benign dysplastic nodules. Clinically, the down-regulation of SULT1A1 was closely associated with an advanced International Union Against Cancer stage and high levels of serum alpha-fetoprotein. In conclusion, the results of this study demonstrate that the loss of SULT1A1 appears to be a characteristic molecular signature of HCC. SULT1A1 might be a useful biomarker for the detection of early HCC and help predict the clinical outcome of patients with HCC.-
dc.formatapplication/pdf-
dc.language.isoen-
dc.subject.MESHAmino Acid Sequence-
dc.subject.MESHArylsulfotransferase-
dc.subject.MESHCarcinoma, Hepatocellular-
dc.subject.MESHDown-Regulation-
dc.subject.MESHElectrophoresis, Gel, Two-Dimensional-
dc.subject.MESHFemale-
dc.subject.MESHGlypicans-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHTumor Markers, Biological-
dc.subject.MESHalpha-Fetoproteins-
dc.titleThe loss of phenol sulfotransferase 1 in hepatocellular carcinogenesis.-
dc.typeArticle-
dc.identifier.pmid19904771-
dc.contributor.affiliatedAuthor여, 말희-
dc.contributor.affiliatedAuthor김, 영배-
dc.contributor.affiliatedAuthor왕, 희정-
dc.contributor.affiliatedAuthor정, 재연-
dc.contributor.affiliatedAuthor이, 광재-
dc.contributor.affiliatedAuthor조, 성원-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/pmic.200900721-
dc.citation.titleProteomics-
dc.citation.volume10-
dc.citation.number2-
dc.citation.date2010-
dc.citation.startPage266-
dc.citation.endPage276-
dc.identifier.bibliographicCitationProteomics, 10(2). : 266-276, 2010-
dc.identifier.eissn1615-9861-
dc.relation.journalidJ016159853-
Appears in Collections:
Journal Papers > Research Organization > Genomic Research Center for Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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