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Association of interleukin-18 gene polymorphisms with hepatitis B virus clearance.

Authors
Cheong, JY; Cho, SW; Oh, B; Kimm, K; Lee, KM; Shin, SJ; Lee, JA; Park, BL; Cheong, HS; Shin, HD; Cho, BY; Kim, JH
Citation
Digestive diseases and sciences, 55(4):1113-1119, 2010
Journal Title
Digestive diseases and sciences
ISSN
0163-21161573-2568
Abstract
The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-gamma-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean subjects were enrolled in the study and divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions -667G>T, -148G>C, +8925C>G, and +13925A>C. We observed that the subjects bearing the IL-18 -148C allele [odds ratio (OR), 0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; P = 0.01) were significantly associated with HBV clearance in a recessive model. This study indicates that the -148C, +8925G, and +13925C alleles of the IL-18 gene are likely associated with HBV clearance in a Korean population.
MeSH terms
AdultAged*AllelesCarrier State/immunologyChromosome MappingConfidence IntervalsFemaleGenes, RecessiveGenotypeHaplotypes/geneticsHepatitis B/*genetics/*immunologyHumansImmunogenetic PhenomenaInterleukin-18/*geneticsLinkage Disequilibrium/genetics/immunologyMaleMiddle AgedOdds RatioPolymorphism, Single Nucleotide/*geneticsProspective StudiesRemission, SpontaneousRepublic of KoreaT-Lymphocytes, Cytotoxic/immunologyYoung Adult
DOI
10.1007/s10620-009-0819-z
PMID
19466545
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
정, 재연조, 성원이, 기명신, 성재김, 진홍
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