Fabrication of MnxFe1-xO colloidal solid solution as a dual magnetic-resonance-contrast agent.
Choi, D; Han, A; Park, JP; Kim, JK; Lee, JH; Kim, TH; Kim, SW
Small (Weinheim an der Bergstrasse, Germany), 5(5):571-573, 2009
Small (Weinheim an der Bergstrasse, Germany)
A study was conducted to demonstrate the fabrication of colloidal Mn xFe1-xO solid-solution nanocrystals and their application as a simultaneous and dual MRI contrast agent for T1- and T 2--weighted imaging. MnxFe1-xO solid-solution nanocrystals were synthesized by the thermal decomposition of iron acetylacetonate(III) and manganese acetylacetonate(II) precursors. Elemental analysis of the solid solution was performed by inductively coupled plasma-atomic emission spectroscopy (ICP-AES) and the energy-dispersive X-ray spectroscopy. Transmission electron microscopy (TEM) investigation revealed 20 nm nanocrystals with a crystalline structure. MRI measurements were also performed on a clinical 1.5-T magnetic resonance scanner at room temperature for three different water-dispersible MnxFe1-xO nanocrystals.
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