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Sirolimus- versus paclitaxel-eluting stents for the treatment of coronary bifurcations results: from the COBIS (Coronary Bifurcation Stenting) Registry.

Authors
Song, YB; Hahn, JY; Choi, SH; Choi, JH; Lee, SH; Jeong, MH; Kim, HS; Seong, IW; Yang, JY; Rha, SW; Jang, Y; Yoon, JH; Tahk, SJ; Seung, KB; Park, SJ; Gwon, HC
Citation
Journal of the American College of Cardiology, 55(16):1743-1750, 2010
Journal Title
Journal of the American College of Cardiology
ISSN
0735-10971558-3597
Abstract
OBJECTIVES: We aimed to compare the long-term clinical outcomes of patients treated with sirolimus-eluting stents (SES) or paclitaxel-eluting stents (PES) for coronary bifurcation lesions.



BACKGROUND: There are limited data regarding comparisons of SES and PES for the treatment of bifurcation lesions.



METHODS: Patients who received percutaneous coronary intervention for non-left main bifurcation lesions were enrolled from 16 centers in Korea between January 2004 and June 2006. We compared major adverse cardiac events (MACE [cardiac death, myocardial infarction, or target lesion revascularization]) between the SES and PES groups in patients overall and in 407 patient pairs generated by propensity-score matching.



RESULTS: We evaluated 1,033 patients with bifurcation lesions treated with SES and 562 patients treated with PES. The median follow-up duration was 22 months. Treatment with SES was associated with a lower incidence of MACE (hazard ratio [HR]: 0.53, 95% confidence interval [CI]: 0.32 to 0.89, p < 0.01) and target lesion revascularization (HR: 0.55, 95% CI: 0.31 to 0.97, p = 0.02), but not of cardiac death (HR: 2.77, 95% CI: 0.40 to 18.99, p = 0.62) and cardiac death or myocardial infarction (HR: 0.97, 95% CI: 0.38 to 2.49, p = 0.94). After propensity-score matching, patients with SES still had fewer MACE and target lesion revascularization incidences than did patients with PES (HR: 0.52, 95% CI: 0.30 to 0.91, p = 0.02, and HR: 0.48, 95% CI: 0.25 to 0.91, p = 0.02, respectively). There was no significant difference in the occurrences of stent thrombosis between the groups (0.7% vs. 0.7%, p = 0.94).



CONCLUSIONS: In patients with bifurcation lesions, the use of SES resulted in better long-term outcomes than did the use of PES, primarily by decreasing the rate of repeat revascularization. (Coronary Bifurcation Stenting Registry in South Korea [COBIS]; NCT00851526).
MeSH terms
AgedAngioplasty, Balloon, Coronary/*instrumentationCoronary AngiographyCoronary Artery Disease/radiography/*surgeryDeath, Sudden, Cardiac/epidemiology/etiology*Drug-Eluting StentsFemaleFollow-Up StudiesHumansImmunosuppressive Agents/pharmacologyIncidenceKorea/epidemiologyMaleMiddle AgedMyocardial Infarction/epidemiology/etiologyPaclitaxel/*pharmacology*RegistriesRetrospective StudiesSirolimus/*pharmacologySurvival Rate/trendsTreatment Outcome
DOI
10.1016/j.jacc.2010.02.008
PMID
20394879
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
AJOU Authors
탁, 승제
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