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Long-term clinical results and predictors of adverse outcomes after drug-eluting stent implantation for bifurcation lesions in a real-world practice: the COBIS (Coronary Bifurcation Stenting) registry.

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dc.contributor.authorGwon, HC-
dc.contributor.authorChoi, SH-
dc.contributor.authorSong, YB-
dc.contributor.authorHahn, JY-
dc.contributor.authorJeong, MH-
dc.contributor.authorSeong, IW-
dc.contributor.authorKim, HS-
dc.contributor.authorRha, SW-
dc.contributor.authorYang, JY-
dc.contributor.authorYoon, JH-
dc.contributor.authorTahk, SJ-
dc.contributor.authorSeung, KB-
dc.contributor.authorJang, Y-
dc.contributor.authorPark, SJ-
dc.date.accessioned2011-05-13T06:19:24Z-
dc.date.available2011-05-13T06:19:24Z-
dc.date.issued2010-
dc.identifier.issn1346-9843-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2591-
dc.description.abstractBACKGROUND: Limited data exists regarding long-term clinical results and predictors of adverse outcomes after drug-eluting stents (DES) implantation for coronary bifurcation lesions in a real-world practice.



METHODS AND RESULTS: A total of 1,691 non-left main bifurcation lesions with side branches ≥2.0mm in 1,668 patients undergoing DES implantation between January 2004 and June 2006 from 16 centers in Korea were evaluated. True bifurcation was found in 69.2% of lesions and 82.7% of lesions were treated with 1-stent technique. During follow-up (median 22 months), cardiac death occurred in 0.9%, myocardial infarction (MI) in 1.2%, target lesion revascularization (TLR) in 4.7% and stent thrombosis in 0.7% of patients. There was no significant difference in major adverse cardiac events (MACE: composite of cardiac death, MI and TLR) between the 1-stent and the 2-stent groups (6.1% vs 7.5%, P=0.36). Stent length in the main vessel (hazard ratio (HR) 1.02, 95% confidence interval (CI) 1.001-1.03, P=0.03), paclitaxel-eluting stent (HR 1.98, 95%CI 1.34-2.92, P=0.001) and kissing ballooning (HR 2.01, 95%CI 1.29-3.13, P=0.002) were independent predictors of MACE. Kissing ballooning increased the risk of MACE especially in the 1-stent group, but not in the 2-stent group.



CONCLUSIONS: In this large real-world registry, overall outcomes after DES implantation in bifurcation lesions were favorable and similar between the 1-stent and 2-stent groups.
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHAngioplasty, Balloon, Coronary-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHCoronary Angiography-
dc.subject.MESHCoronary Stenosis-
dc.subject.MESHDrug-Eluting Stents-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMyocardial Infarction-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProsthesis Design-
dc.subject.MESHRegistries-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Assessment-
dc.subject.MESHRisk Factors-
dc.subject.MESHThrombosis-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleLong-term clinical results and predictors of adverse outcomes after drug-eluting stent implantation for bifurcation lesions in a real-world practice: the COBIS (Coronary Bifurcation Stenting) registry.-
dc.typeArticle-
dc.identifier.pmid20890049-
dc.identifier.urlhttp://joi.jlc.jst.go.jp/JST.JSTAGE/circj/CJ-10-0352?from=PubMed-
dc.contributor.affiliatedAuthor탁, 승제-
dc.type.localJournal Papers-
dc.citation.titleCirculation journal-
dc.citation.volume74-
dc.citation.number11-
dc.citation.date2010-
dc.citation.startPage2322-
dc.citation.endPage2328-
dc.identifier.bibliographicCitationCirculation journal, 74(11). : 2322-2328, 2010-
dc.identifier.eissn1347-4820-
dc.relation.journalidJ013469843-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
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