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Comparison of the long-term outcomes between proximal and distal IgG4-related sclerosing cholangitis: A multicenter cohort study
DC Field | Value | Language |
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dc.contributor.author | Cho, SH | - |
dc.contributor.author | Song, TJ | - |
dc.contributor.author | Park, JS | - |
dc.contributor.author | Yoon, JH | - |
dc.contributor.author | Yang, MJ | - |
dc.contributor.author | Yoon, SB | - |
dc.contributor.author | Lee, JM | - |
dc.contributor.author | Lee, YN | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Choi, EK | - |
dc.contributor.author | Park, SW | - |
dc.contributor.author | Oh, D | - |
dc.contributor.author | Park, DH | - |
dc.contributor.author | Lee, SS | - |
dc.contributor.author | Seo, DW | - |
dc.contributor.author | Lee, SK | - |
dc.contributor.author | Kim, MH | - |
dc.date.accessioned | 2023-06-14T02:52:27Z | - |
dc.date.available | 2023-06-14T02:52:27Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/25929 | - |
dc.description.abstract | Background and Aims: Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is considered a biliary manifestation of IgG4-related diseases. However, there has been a controversy on the clinical outcomes according to the location of the involved bile duct. We therefore compared the clinical outcomes and long-term prognosis of IgG4-SC with proximal bile duct involvement (proximal IgG4-SC) and IgG4-SC with distal bile duct involvement (distal IgG4-SC). Methods: We reviewed the data of patients with IgG4-SC that were prospectively collected at 10 tertiary centers between March 2002 and October 2020. Clinical manifestations, outcomes, association with autoimmune pancreatitis (AIP), steroid-responsiveness, and relapse of IgG4-SC were evaluated. Results: A total of 148 patients (proximal IgG4-SC, n = 59; distal IgG4-SC, n = 89) were analyzed. The median age was 65 years (IQR, 56.25–71), and 86% were male. The two groups were similar in terms of jaundice at initial presentation (51% vs 65%; P = 0.082) and presence of elevated serum IgG4 (66% vs 70%; P = 0.649). The two groups showed significant differences in terms of steroid-responsiveness (91% vs 100%; P = 0.008), association with AIP (75% vs 99%; P = 0.001), and occurrence of liver cirrhosis (9% vs 1%; P = 0.034). During a median follow-up of 64 months (IQR, 21.9–84.7), the cumulative relapse-free survival was significantly different between the two groups (67% vs 79% at 5 years; P = 0.035). Conclusions: Relapse of IgG4-SC frequently occurred during follow-up. Proximal IgG4-SC and distal IgG4-SC had different long-term outcomes in terms of steroid-responsiveness, occurrence of liver cirrhosis, and recurrence. It may be advantageous to determine the therapeutic and follow-up strategies according to the location of bile duct involvement. | - |
dc.language.iso | en | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Autoimmune Diseases | - |
dc.subject.MESH | Autoimmune Pancreatitis | - |
dc.subject.MESH | Cholangitis, Sclerosing | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin G | - |
dc.subject.MESH | Liver Cirrhosis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Multicenter Studies as Topic | - |
dc.subject.MESH | Steroids | - |
dc.title | Comparison of the long-term outcomes between proximal and distal IgG4-related sclerosing cholangitis: A multicenter cohort study | - |
dc.type | Article | - |
dc.identifier.pmid | 36710432 | - |
dc.subject.keyword | Autoimmune disease | - |
dc.subject.keyword | Cholangitis | - |
dc.subject.keyword | Immunoglobulin G | - |
dc.subject.keyword | Immunoglobulin G4-related disease | - |
dc.subject.keyword | Sclerosing | - |
dc.contributor.affiliatedAuthor | Yang, MJ | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1111/jgh.16136 | - |
dc.citation.title | Journal of gastroenterology and hepatology | - |
dc.citation.volume | 38 | - |
dc.citation.number | 4 | - |
dc.citation.date | 2023 | - |
dc.citation.startPage | 648 | - |
dc.citation.endPage | 655 | - |
dc.identifier.bibliographicCitation | Journal of gastroenterology and hepatology, 38(4). : 648-655, 2023 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.identifier.eissn | 1440-1746 | - |
dc.relation.journalid | J008159319 | - |
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