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A link between CD8+CD27-CD28- T cells expressing chemerin chemokine-like receptor 1 and rheumatoid arthritis

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dc.contributor.authorJeong, E-
dc.contributor.authorJung, JY-
dc.contributor.authorLee, MJ-
dc.contributor.authorKim, HA-
dc.contributor.authorYang, HY-
dc.contributor.authorKim, K-
dc.contributor.authorPark, S-
dc.date.accessioned2023-06-14T02:52:27Z-
dc.date.available2023-06-14T02:52:27Z-
dc.date.issued2023-
dc.identifier.issn0392-856X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/25930-
dc.description.abstractOBJECTIVES: Transcription of the chemerin chemokine-like receptor 1 (CMKLR1) has been observed in T cell subsets, but its role in T cells has not been well studied. As previously reported, the levels of its ligand, chemerin, are increased in the plasma and synovial fluid of patients with rheumatoid arthritis (RA); hence, we aimed to explore the expression and role of CMKLR1 in the T cells of these patients. METHODS: Peripheral blood and synovial fluid from patients with RA or osteoarthritis and healthy individuals were collected to analyse the frequency of CD27-CD28- T cells and the expression of CMKLR1 and TNF-α by flow cytometry. Chemotaxis of T cells was assessed using a Transwell migration assay. Chemerin levels were measured using an enzyme-linked immunosorbent assay. RESULTS: CMKLR1 was preferentially expressed in CD27-CD28- T cell subsets. Its surface levels were reduced by stimulation with anti-CD3 antibody or chemerin. We found a correlation between CMKLR1+CD8+CD27-CD28- T cell frequency and disease activity score 28 of RA. Chemerin treatment up-regulated but CMKLR1 inhibitor treatment down-regulated TNF-α expression in CD8+CD27-CD28- T cells, half of which express CMKLR1 on average. Moreover, chemerin induced migration of these cells. Analysis of blood and synovial fluid samples of RA showed a reduction of CMKLR1+CD27-CD28- T cell levels in the synovial fluid, with a few exceptions. CONCLUSIONS: Our results suggest that CMKLR1 expression in T cells may be involved in RA pathogenesis through modulation of TNF-α expression and cell migration.-
dc.language.isoen-
dc.subject.MESHArthritis, Rheumatoid-
dc.subject.MESHCD28 Antigens-
dc.subject.MESHCD8-Positive T-Lymphocytes-
dc.subject.MESHChemokines-
dc.subject.MESHHumans-
dc.subject.MESHTumor Necrosis Factor-alpha-
dc.titleA link between CD8+CD27-CD28- T cells expressing chemerin chemokine-like receptor 1 and rheumatoid arthritis-
dc.typeArticle-
dc.identifier.pmid36200942-
dc.contributor.affiliatedAuthorJung, JY-
dc.contributor.affiliatedAuthorKim, HA-
dc.contributor.affiliatedAuthorKim, K-
dc.contributor.affiliatedAuthorPark, S-
dc.type.localJournal Papers-
dc.identifier.doi10.55563/clinexprheumatol/52v1bb-
dc.citation.titleClinical and experimental rheumatology-
dc.citation.volume41-
dc.citation.number5-
dc.citation.date2023-
dc.citation.startPage1105-
dc.citation.endPage1113-
dc.identifier.bibliographicCitationClinical and experimental rheumatology, 41(5). : 1105-1113, 2023-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1593-098X-
dc.relation.journalidJ00392856X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
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