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Three phenotypes of obstructive lung disease in the elderly.

Authors
Jo, KW; Ra, SW; Chae, EJ; Seo, JB; Kim, NK; Lee, JH; Kim, EK; Lee, YK; Kim, TH; Huh, JW; Kim, WJ; Lee, SM; Lim, SY; Shin, TR; Yoon, HI; Sheen, SS; Lee, JS; Lee, SD; Oh, YM
Citation
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 14(11):1481-1488, 2010
Journal Title
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
ISSN
1027-37191815-7920
Abstract
SETTING: Eleven referring hospitals in South Korea.



OBJECTIVE: To classify the phenotypes in elderly subjects with obstructive lung disease (OLD).



METHODS: We analysed 191 subjects aged ≥ 60 years with chronic respiratory symptoms and either obstructive spirometry or bronchial hyperresponsiveness. Factor analysis was performed using commonly measured variables and revealed four significant variables: 1) the ratio of inspiratory capacity to total lung capacity, 2) the total score on the St George's Respiratory Questionnaire, 3) the volume fraction of the lung less than 950 Hounsfield Unit at full inspiration on volumetric computed tomography and 4) post-bronchodilator forced expiratory volume in 1 second (FEV(1)) changes. We performed a cluster analysis on these four variables.



RESULTS: The mean age was 68.5 (± 5.2 SD) years and the mean post-bronchodilator FEV(1) was 52.4% (± 16.5) predicted. Three clusters with the following phenotypes were identified: Cluster 1 included subjects with moderate to severe airflow obstruction and bronchodilator reversibility; Cluster 2 subjects had moderate airflow obstruction without bronchodilator reversibility, and Cluster 3 subjects had severe airflow obstruction without bronchodilator reversibility.



CONCLUSIONS: We identified three phenotypes in elderly subjects with OLD. Follow-up studies are needed to explore the clinical significance of each phenotype.
MeSH terms
AgedBronchial Hyperreactivity/*etiologyBronchodilator Agents/*pharmacologyCluster AnalysisFemaleForced Expiratory VolumeHumansLung Diseases, Obstructive/classification/drug therapy/*physiopathologyMaleMiddle AgedPhenotypeRepublic of KoreaSeverity of Illness IndexSpirometryTotal Lung Capacity
PMID
20937191
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
AJOU Authors
신, 승수
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