39 291

Cited 0 times in

Normal range of alanine aminotransferase concentration is associated with carotid atherosclerosis.

Authors
Kim, SK; Kim, DJ; Kim, SH; Lee, YK; Park, SW; Cho, YW; Huh, KB
Citation
Diabetes research and clinical practice, 88(1):111-116, 2010
Journal Title
Diabetes research and clinical practice
ISSN
0168-82271872-8227
Abstract
OBJECTIVE: To investigate whether alanine aminotransferase (ALT), even within the reference range, is associated with atherosclerotic burden in apparently healthy adults.



METHODS: This was an observational study performed on 830 healthy individuals with normal ALT concentration (<or=40U/L). Atherosclerotic burden was assessed by carotid arterial intima-media thickness (IMT). All subjects were divided according to the quartile based on their ALT concentrations.



RESULTS: Despite all subjects having a normal ALT concentration, ultrasonographic liver steatosis was observed in 48.4% and 36.7% of men and women, respectively. In both genders, subjects in the highest quartile of ALT concentration had a significantly higher waist circumference, triglyceride concentration, HOMA-IR, a higher prevalence of metabolic syndrome, and a greater severity of ultrasonographic liver steatosis than did those in the lower quartiles. In women, the carotid IMT increased significantly with increasing quartiles of ALT concentration (0.62+/-0.14mm, 0.66+/-0.15mm, 0.69+/-0.15mm, vs. 0.72+/-0.24mm; P for trend<0.001). Based on multivariate regression analysis, the serum ALT, even within the normal range, was associated with the carotid IMT in both men and women, and independently of traditional cardiovascular risk factors.



CONCLUSIONS: ALT concentrations, albeit within the reference range, were associated with atherosclerotic burden in healthy adults.
MeSH terms
AdultAlanine Transaminase/*bloodCarotid Artery Diseases/*blood/*ultrasonographyFatty Liver/*blood/*ultrasonographyFemaleHumansInsulin Resistance/physiologyMaleMetabolic Syndrome X/blood/ultrasonographyMiddle AgedReference ValuesRegression AnalysisTunica Intima/ultrasonographyTunica Media/ultrasonographyWaist Circumference/physiology
DOI
10.1016/j.diabres.2010.01.003
PMID
20092904
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
김, 대중
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse