20 251

Cited 21 times in

High expression of excision repair cross-complementation group 1 protein predicts poor outcome in patients with nasopharyngeal cancer.

Authors
Lee, HW; Hwang, YH; Han, JH; Choi, JH; Kang, SY; Jeong, SH; Ann, MS; Oh, YT; Kim, JH; Kim, CH; Sheen, SS
Citation
Oral oncology, 46(3):209-213, 2010
Journal Title
Oral oncology
ISSN
1368-83751879-0593
Abstract
We evaluated the prognostic significance of excision repair cross-complementation group 1 protein (ERCC1) and thymidylate synthase (TS) in patients with nasopharyngeal cancer (NPC) treated with concurrent chemoradiotherapy (CCRT). Pre-treatment tumor biopsy specimens from 41 patients with locally advanced NPC (stage I: 1, II: 10, III: 9, IV: 21 patients) were analyzed for ERCC1 and TS expression by immunohistochemistry. All patients were treated with one cycle of induction chemotherapy (5-fluorouracil 1000 mg/m(2)/day and cisplatin 20mg/m(2)/day, days 1-4) followed by CCRT starting on day 22. CCRT consisted of radiotherapy (70 Gy/35 fractions for 7 weeks) with cisplatin 20mg/m(2)/day for 4 days on weeks 1, 4, and 7 of radiotherapy. High expression of ERCC1 and TS was observed in 25 (60%) and 21 (51%) patients, respectively. High expression of ERCC1 was associated with WHO type 1 or 2 histology (p=0.045). With a median follow-up duration of 106 months (32-152 months) in survivors, the 5-year overall survival (OS) of all patients was 53%. In univariate analysis, 5-year OS (73% versus 39%, p=0.005) was significantly inferior in patients with high expression of ERCC1, while high expression of TS was not correlated with patient outcome. In multivariate analysis, high expression of ERCC1 was a significant independent prognostic factor for poor OS (p=0.029) along with WHO type 1 or 2 histology. High expression of ERCC1 protein may be a useful prognostic factor for poor outcome in patients with locally advanced NPC treated with CCRT.
MeSH terms
AdultAgedAsia, SoutheasternDNA-Binding Proteins/genetics/*metabolismEndonucleases/genetics/*metabolismFemaleHumansImmunohistochemistryMaleMiddle AgedNasopharyngeal Neoplasms/drug therapy/*metabolismNeoplasm Proteins/genetics/*metabolismPrognosisThymidylate Synthase/*metabolismYoung Adult
DOI
10.1016/j.oraloncology.2009.12.007
PMID
20153243
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
AJOU Authors
이현우한재호최진혁강석윤정성현안미선오영택김장희김철호신승수
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse