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Activation of human monocytes by a formyl peptide receptor 2-derived pepducin.

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dc.contributor.authorLee, HY-
dc.contributor.authorKim, SD-
dc.contributor.authorShim, JW-
dc.contributor.authorKim, HJ-
dc.contributor.authorKwon, JY-
dc.contributor.authorKim, JM-
dc.contributor.authorBaek, SH-
dc.contributor.authorPark, JS-
dc.contributor.authorBae, YS-
dc.date.accessioned2011-05-17-
dc.date.available2011-05-17-
dc.date.issued2010-
dc.identifier.issn0014-5793-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2610-
dc.description.abstractWe synthesized and investigated the effect of formyl peptide receptor 2 (FPR2)-derived pepducins in human monocytes. The FPR2-based cell-penetrating lipopeptide, "pepducin" (F2pal-16), stimulated intracellular calcium increase in human monocytes via pertussis toxin (PTX)-sensitive G-protein and phospholipase C (PLC) activity. From a functional aspect, we showed that F2pal-16 stimulated monocyte chemotaxis. F2pal-16 also stimulated the generation of superoxide anion in human monocytes. Moreover, F2pal-16 dramatically increased the production of several kinds of pro-inflammatory cytokines (CXCL8, CCL2, IL-1β and TNF-α) in human monocytes via NF-κB activation. Since FPR2 plays an important role in immune responses, F2pal-16 can serve as a useful reagent for the study of FPR2-mediated immune modulation.-
dc.language.isoen-
dc.subject.MESHAmino Acid Sequence-
dc.subject.MESHCalcium-
dc.subject.MESHCells, Cultured-
dc.subject.MESHChemokine CCL2-
dc.subject.MESHChemotaxis-
dc.subject.MESHCytokines-
dc.subject.MESHHumans-
dc.subject.MESHLipopeptides-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHMonocytes-
dc.subject.MESHNF-kappa B-
dc.subject.MESHReceptors, Formyl Peptide-
dc.subject.MESHReceptors, Lipoxin-
dc.subject.MESHSuperoxides-
dc.titleActivation of human monocytes by a formyl peptide receptor 2-derived pepducin.-
dc.typeArticle-
dc.identifier.pmid20804753-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0014-5793(10)00698-8-
dc.contributor.affiliatedAuthor박, 준성-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.febslet.2010.08.036-
dc.citation.titleFEBS letters-
dc.citation.volume584-
dc.citation.number18-
dc.citation.date2010-
dc.citation.startPage4102-
dc.citation.endPage4108-
dc.identifier.bibliographicCitationFEBS letters, 584(18). : 4102-4108, 2010-
dc.identifier.eissn1873-3468-
dc.relation.journalidJ000145793-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
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