Cited 0 times in Scipus Cited Count

GNAQ-Regulated ZO-1 and ZO-2 Act as Tumor Suppressors by Modulating EMT Potential and Tumor-Repressive Microenvironment in Lung Cancer

DC Field Value Language
dc.contributor.authorKim, HS-
dc.contributor.authorLee, SI-
dc.contributor.authorChoi, YR-
dc.contributor.authorKim, J-
dc.contributor.authorEun, JW-
dc.contributor.authorSong, KS-
dc.contributor.authorJeong, JY-
dc.date.accessioned2023-07-06T06:02:57Z-
dc.date.available2023-07-06T06:02:57Z-
dc.date.issued2023-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/26157-
dc.description.abstractEpithelial-to-mesenchymal transition (EMT) plays a critical role in the development and progression of lung cancer by promoting its invasiveness and metastasis. Using integrative analyses of the public lung cancer database, we found that the expression levels of the tight junction proteins, zonula occluden (ZO)-1 and ZO-2, were lower in lung cancer tissues, including both lung adenocarcinoma and lung squamous cell carcinoma than in normal lung tissues analyzed using The Cancer Genome Atlas (TCGA). Although the ectopic expression or knockdown of ZO-1 and ZO-2 did not affect the growth of lung cancer cells, they significantly regulated cell migration and invasion. When M0 macrophages were co-cultured with ZO-1 or ZO-2 knockdown Calu-1 cells, M2-like polarization was efficiently induced. Conversely, co-culture of M0 THP-1 cells with A549 cells stably expressing ZO-1 or ZO-2 significantly reduced M2 differentiation. We also identified G protein subunit alpha q (GNAQ) as a potential ZO-1- and ZO-2-specific activator through analysis of correlated genes with the TCGA lung cancer database. Our results suggest that the GNAQ-ZO-1/2 axis may play a tumor-suppressive role in lung cancer development and progression and highlight ZO-1 and ZO-2 as key EMT- and tumor microenvironment-suppressive proteins. These findings provide new insights for the development of targeted therapies for lung cancer.-
dc.language.isoen-
dc.subject.MESHAdenocarcinoma of Lung-
dc.subject.MESHEpithelial-Mesenchymal Transition-
dc.subject.MESHGTP-Binding Protein alpha Subunits, Gq-G11-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms-
dc.subject.MESHTight Junctions-
dc.subject.MESHTumor Microenvironment-
dc.subject.MESHZonula Occludens-1 Protein-
dc.titleGNAQ-Regulated ZO-1 and ZO-2 Act as Tumor Suppressors by Modulating EMT Potential and Tumor-Repressive Microenvironment in Lung Cancer-
dc.typeArticle-
dc.identifier.pmid37240145-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218451-
dc.subject.keywordG protein subunit alpha q-
dc.subject.keywordlung cancer-
dc.subject.keywordtight junctions-
dc.subject.keywordtumor microenvironment-
dc.subject.keywordzonula occludens-
dc.contributor.affiliatedAuthorEun, JW-
dc.type.localJournal Papers-
dc.identifier.doi10.3390/ijms24108801-
dc.citation.titleInternational journal of molecular sciences-
dc.citation.volume24-
dc.citation.number10-
dc.citation.date2023-
dc.citation.startPage8801-
dc.citation.endPage8801-
dc.identifier.bibliographicCitationInternational journal of molecular sciences, 24(10). : 8801-8801, 2023-
dc.identifier.eissn1422-0067-
dc.relation.journalidJ014220067-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Files in This Item:
37240145.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse