Cited 0 times in Scipus Cited Count

Comparison of automated quantification of amyloid deposition between PMOD and Heuron

DC Field Value Language
dc.contributor.authorRoh, HW-
dc.contributor.authorSon, SJ-
dc.contributor.authorHong, CH-
dc.contributor.authorMoon, SY-
dc.contributor.authorLee, SM-
dc.contributor.authorSeo, SW-
dc.contributor.authorChoi, SH-
dc.contributor.authorKim, EJ-
dc.contributor.authorCho, SH-
dc.contributor.authorKim, BC-
dc.contributor.authorPark, S-
dc.contributor.authorSong, S-
dc.contributor.authorAn, YS-
dc.date.accessioned2023-07-06T06:02:59Z-
dc.date.available2023-07-06T06:02:59Z-
dc.date.issued2023-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/26168-
dc.description.abstractSeveral programs are widely used for clinical and research purposes to automatically quantify the degree of amyloid deposition in the brain using positron emission tomography (PET) images. Given that very few studies have investigated the use of Heuron, a PET image quantification software approved for clinical use, this study aimed to compare amyloid deposition values quantified from 18F-flutemetamol PET images using PMOD and Heuron. Amyloid PET data obtained from 408 patients were analysed using each quantitative program; moreover, the standardized uptake value ratios (SUVRs) of target areas were obtained by dividing the standardized uptake value (SUV) of the target region by the SUV of cerebellar grey matter as a reference. Compared with PMOD, Heuron yielded significantly higher SUVRs for all target areas (paired sample t-test, p < 0.001), except for the PC/PCC (p = 0.986). However, the Bland–Altman plot analysis indicated that the two quantitative methods may be used interchangeably. Moreover, receiver operating characteristic curve analysis revealed no significant between-method difference in the performance of the SUVRs in evaluating the visual positivity of amyloid deposits (p = 0.948). In conclusion, Heuron and PMOD have comparable performance in quantifying the degree of amyloid deposits in PET images.-
dc.language.isoen-
dc.subject.MESHAlzheimer Disease-
dc.subject.MESHAmyloid-
dc.subject.MESHAmyloid beta-Peptides-
dc.subject.MESHAmyloidogenic Proteins-
dc.subject.MESHAniline Compounds-
dc.subject.MESHBrain-
dc.subject.MESHHumans-
dc.subject.MESHPlaque, Amyloid-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHROC Curve-
dc.titleComparison of automated quantification of amyloid deposition between PMOD and Heuron-
dc.typeArticle-
dc.identifier.pmid37336977-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279744-
dc.contributor.affiliatedAuthorRoh, HW-
dc.contributor.affiliatedAuthorSon, SJ-
dc.contributor.affiliatedAuthorHong, CH-
dc.contributor.affiliatedAuthorMoon, SY-
dc.contributor.affiliatedAuthorLee, SM-
dc.contributor.affiliatedAuthorAn, YS-
dc.type.localJournal Papers-
dc.identifier.doi10.1038/s41598-023-36986-5-
dc.citation.titleScientific reports-
dc.citation.volume13-
dc.citation.number1-
dc.citation.date2023-
dc.citation.startPage9891-
dc.citation.endPage9891-
dc.identifier.bibliographicCitationScientific reports, 13(1). : 9891-9891, 2023-
dc.identifier.eissn2045-2322-
dc.relation.journalidJ020452322-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
Files in This Item:
37336977.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse