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Serum lactoferrin level as a serologic biomarker for allergic rhinitis.

Authors
Choi, GS; Shin, SY; Kim, JH; Lee, HY; Palikhe, NS; Ye, YM; Kim, SH; Park, HS
Citation
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 40(3):403-410, 2010
Journal Title
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
ISSN
0954-78941365-2222
Abstract
BACKGROUND: Allergic rhinitis (AR) is a very common disease and a risk factor for allergic asthma. The discovery of new biomarkers for the early detection of AR would improve the clinical outcomes and reduce socio-economic burden. We sought to identify a novel serologic marker for detection of AR using a proteomic approach. METHODS: To identify the proteins involved in AR, comparative proteomics was applied using nasal lavage fluids (NLFs) taken before and after a nasal provocation test (NPT) with Dermatophagoides pteronyssinus (Dpt) in a subject with AR sensitized to Dpt. The clinical relevance of the identified proteins was evaluated by ELISA using NLFs and sera from the three study groups: Dpt-sensitive AR; asymptomatic Dpt-sensitive controls; and non-atopic healthy controls. The sensitivities and specificities of the candidate proteins for predicting AR were determined using receiver operating characteristic (ROC) curves. RESULTS: In proteomic analysis, lactoferrin expression was up-regulated after NPT. The validation study using ELISA showed a significantly lower serum lactoferrin level in the AR group than those of the other two groups (P<0.05, respectively). To discriminate between subjects with or without AR, the optimal serum cut-off level of lactoferrin was set at <307 ng/mL using the ROC curve. The sensitivity and specificity for predicting AR were 81.4% and 58%. When combined with serum Dpt-specific IgE level, the sensitivity and specificity for predicting AR were 76.7% and 79.2%. CONCLUSION: These results suggest that the serum lactoferrin level is associated with the phenotype of Dpt-sensitive AR, and in combination with the serum Dpt-specific IgE level, may be a potential serologic marker for early detection of AR.
MeSH terms
AdultAnimalsBiological Markers/bloodDermatophagoides pteronyssinus/immunologyEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin E/blood/immunologyLactoferrin/*blood/immunologyMalePhenotypeRhinitis, Allergic, Perennial/*blood/diagnosis/immunologySensitivity and SpecificitySkin Tests
DOI
10.1111/j.1365-2222.2009.03414.x
PMID
20015277
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
최길순김장희예영민김승현박해심
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