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Immunoglobulin G subclass deficiency is the major phenotype of primary immunodeficiency in a Korean adult cohort.

Authors
Kim, JH; Park, HJ; Choi, GS; Kim, JE; Ye, YM; Nahm, DH; Park, HS
Citation
Journal of Korean medical science, 25(6):824-828, 2010
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Primary immunodeficiency disease (PID) is a rare disorder in adults. Most often, serious forms are detected during infancy or childhood. However, mild forms of PID may not be diagnosed until later in life, and some types of humoral immunodeficiency may occur in adulthood. The purpose of this study was to identify clinical features of PID in Korean adults. A retrospective study was performed on 55 adult patients who were diagnosed as PID between January 1998 and January 2009 at a single tertiary medical center in Korea. IgG subclass deficiency was the most common phenotype (67%, 37/55), followed by total IgG deficiency (20%, 11/55), IgM deficiency (7%, 4/55), common variable immunodeficiency (2%, 1/55), and X-linked agammaglobulinemia (2%, 1/55). IgG3 and IgG4 were the most affected subclasses. Upper and lower respiratory tract infections (76%) were the most frequently observed symptoms, followed by multiple site infection (11%), urinary tract infection, and colitis. Bronchial asthma, rhinitis, and several autoimmune diseases were common associated diseases. IgG and IgG subclass deficiency should be considered in adult patients presenting with recurrent upper and lower respiratory infections, particularly in those with respiratory allergies or autoimmune diseases.
MeSH terms
AdolescentAdultAgedCohort StudiesCommon Variable Immunodeficiency/diagnosis/epidemiologyFemaleHumansHyper-IgM Immunodeficiency Syndrome/diagnosis/epidemiologyIgG Deficiency/classification/*diagnosis/epidemiologyImmunologic Deficiency Syndromes/complications/*diagnosis/epidemiologyMaleMiddle AgedPhenotypeRepublic of Korea/epidemiologyRespiratory Tract Infections/etiologyRetrospective StudiesX-Linked Combined Immunodeficiency Diseases/diagnosis/epidemiology
DOI
10.3346/jkms.2010.25.6.824
PMID
20514300
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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김주희최길순김정은예영민남동호박해심
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