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Genetic polymorphisms of ADRB2 and IL10 may be associated with the risk of IgE sensitization to digestive powders in exposed medical personnel.

Authors
Ye, YM; Lee, HY; Kim, SH; Park, HS
Citation
International archives of allergy and immunology, 153(2):193-200, 2010
Journal Title
International archives of allergy and immunology
ISSN
1018-24381423-0097
Abstract
BACKGROUND: It has been reported that pancreatic extracts may induce IgE-mediated respiratory allergy in medical personnel. The aim of the study was to identify genetic factors associated with IgE sensitization to digestive powders containing pancreatic extract. METHODS: This case-control study was performed on 153 subjects routinely exposed to digestive powder and on 123 nonexposed controls working in Ajou University Hospital. Skin prick testing was performed using 4 commonly used digestive powders and α-amylase. Serum specific IgE levels were measured by ELISA. Three single nucleotide polymorphisms, ADRB2 46A>G, IL10 -1082A>G and IL4 -589T>C, were genotyped using the single base extension method. RESULTS: The positive rate of serum specific IgE to digestive powder was significantly higher in the 41 (26.8%) exposed personnel with work-related respiratory symptoms than in controls (24.4 vs. 5.4%, p = 0.012). Thirty-nine (25.5%) of the 153 exposed personnel were found to have an allergy to digestive powder, as determined by a positive skin prick test and/or a high serum specific IgE level to digestive powder. The ADRB2 46A>G and IL10 -1082A>G polymorphisms were found to be significantly associated with the development of an allergy to digestive powder in exposed medical personnel by multiple logistic regression analysis after controlling for age, atopy and job type (pharmacist or nurse; p = 0.035 and p = 0.027, respectively). CONCLUSION: These results suggest that the genetic polymorphisms ADRB2 46A>G and IL10 -1082A>G are genetic factors that increase IgE sensitization to pancreatic extracts in medical personnel occupationally exposed to digestive powders.
MeSH terms
AdultFemale*Health PersonnelHumansHypersensitivity/*etiology/geneticsImmunoglobulin E/*bloodInterleukin-10/*geneticsMaleMiddle AgedOccupational Diseases/*etiology/geneticsPancreatic Extracts/*immunologyPancrelipase/immunology*Polymorphism, Single NucleotidePowdersReceptors, Adrenergic, beta-2/*geneticsRiskSkin Tests
DOI
10.1159/000312637
PMID
20413987
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
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