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Prevalence of human papilloma virus infections and cervical cytological abnormalities among Korean women with systemic lupus erythematosus.

Authors
Lee, YH; Choe, JY; Park, SH; Park, YW; Lee, SS; Kang, YM; Nam, EJ; Park, W; Kwon, SR; Bae, SC; Kim, YJ; Suh, CH; Kim, HA; Hur, NW; Lee, J
Citation
Journal of Korean medical science, 25(10):1431-1437, 2010
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
We performed a multicenter cross-sectional study of 134 sexually active systemic lupus erythematosus (SLE) patients to investigate the prevalence of and risk factors for high risk human papilloma virus (HPV) infection and cervical cytological abnormalities among Korean women with SLE. In this multicenter cross-sectional study, HPV testing and routine cervical cytologic examination was performed. HPV was typed using a hybrid method or the polymerase chain reaction. Data on 4,595 healthy women were used for comparison. SLE patients had greater prevalence of high-risk HPV infection (24.6% vs. 7.9%, P<0.001, odds ratio 3.8, 95% confidence interval 2.5-5.7) and of abnormal cervical cytology (16.4 vs. 2.8%, P<0.001, OR 4.4, 95% CI 2.5-7.8) compared with controls. SLE itself was identified as independent risk factors for high risk HPV infection among Korean women (OR 3.8, 95% CI 2.5-5.7) along with ≥2 sexual partners (OR 8.5, 95% CI 1.2-61.6), and Pap smear abnormalities (OR 97.3, 95% CI 6.5-1,456.7). High-risk HPV infection and cervical cytological abnormalities were more common among Korean women with SLE than controls. SLE itself may be a risk factor for HPV infection among Korean women, suggesting the importance of close monitoring of HPV infections and abnormal Pap smears in SLE patients.
MeSH terms
AdultCervix Uteri/*pathologyCross-Sectional StudiesFemaleHumansLupus Erythematosus, Systemic/*complications/pathologyMiddle AgedOdds RatioPapillomavirus Infections/complications/*epidemiologyPrevalenceRepublic of KoreaRisk FactorsVaginal SmearsWomen
DOI
10.3346/jkms.2010.25.10.1431
PMID
20890422
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
서, 창희김, 현아
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