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Prognostic impacts of participation in prospective surgical clinical trials on surgical outcomes in gastric cancer patients

Song, JH  | Shin, HJ  | Son, SY  | Hur, H  | Han, SU
Scientific reports, 13(1). : 14914-14914, 2023
Journal Title
Scientific reports
Various prospective surgical trials have been conducted on treating patients with gastric cancer. In clinical practice, patients and surgeons may hesitate to participate in prospective surgical trials due to trial-related complications. In this study, we evaluated the effects of participation in prospective surgical trials on surgical outcomes after radical gastrectomy for gastric cancer. This study included 1689 patients who underwent curative gastrectomy for gastric cancer between 2016 and 2020. The propensity score weighting (PSW) method was used to adjust for differences in baseline clinicopathological characteristics between patients who participated and those who did not participate in prospective surgical clinical trials. Perioperative outcomes and overall survival were compared between groups. Of the 1689 patients, 309 (18.3%) participated in surgical clinical trials (SCT group). Before PSW, the SCT group had a similar operation time, intraoperative blood loss, complications, major complications, and hospital stay as the non-SCT group but had superior overall survival. After PSW, overall survival and perioperative outcomes were not significantly different between the groups. The present study suggests that participation in prospective surgical trials was not associated with surgical outcomes. Patients and surgeons may participate in prospective surgical trials without fearing adverse effects on surgical outcomes.

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Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Ajou Authors
손, 상용  |  송, 정호  |  신, 호정  |  한, 상욱  |  허, 훈
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