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Subthalamic deep brain stimulation improves vascular endothelial function in Parkinson's disease

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dc.contributor.authorPark, DG-
dc.contributor.authorKim, MS-
dc.contributor.authorShin, IJ-
dc.contributor.authorYoon, JH-
dc.date.accessioned2023-11-09T05:00:30Z-
dc.date.available2023-11-09T05:00:30Z-
dc.date.issued2023-
dc.identifier.issn1353-8020-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/26506-
dc.description.abstractObjectives: Vascular health (white matter change, vascular risk factor, angiogenesis, microvascular alteration) is associated with clinical progression or levodopa-induced dyskinesia in PD. Vascular endothelial function is known to reflect the earliest vascular change. While DBS can improve motor and non-motor symptoms, the effect of DBS on vascular endothelial function is unknown. Thus, we aimed to investigate whether DBS surgery could impact vascular endothelial function in PD. Method: A total of 20 PD patients were recruited. Vascular endothelial function was evaluated with flow-mediated dilation (FMD). FMD was investigated before and after one year of DBS surgery. Results: FMD improved (6.01 ± 1.58 to 6.84 ± 1.57, p = 0.027). While the level of homocysteine slightly decreased (13.8 ± 4.1 to 13.0 ± 3.2, p = 0.05), there was no significant correlation between FMD changes and homocysteine levels (r = 0.42, p = 0.065). FMD change was associated with baseline age (r = −0.59, p = 0.006) but not with disease duration (p = 0.73), baseline UPDRS III (p = 0.81), change of UPDRS III and dyskinesia, and LEDD change (p = 0.94). Multivariate linear regression analysis revealed that only age (B = −0.139; p = 0.024) was significantly and inversely correlated with the change of FMD. Conclusions: We found that STN-DBS improves vascular endothelial function in PD. Further studies are needed to clarify the exact pathogenesis and clinical implication of beneficial effects on vascular endothelial dysfunction in PD.-
dc.language.isoen-
dc.titleSubthalamic deep brain stimulation improves vascular endothelial function in Parkinson's disease-
dc.typeArticle-
dc.identifier.pmid37844349-
dc.subject.keywordDeep brain stimulation-
dc.subject.keywordEndothelial function-
dc.subject.keywordParkinson's disease-
dc.subject.keywordVascular-
dc.contributor.affiliatedAuthorPark, DG-
dc.contributor.affiliatedAuthorShin, IJ-
dc.contributor.affiliatedAuthorYoon, JH-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.parkreldis.2023.105882-
dc.citation.titleParkinsonism & related disorders-
dc.citation.volume116-
dc.citation.date2023-
dc.citation.startPage105882-
dc.citation.endPage105882-
dc.identifier.bibliographicCitationParkinsonism & related disorders, 116. : 105882-105882, 2023-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.identifier.eissn1873-5126-
dc.relation.journalidJ013538020-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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