Cited 0 times in
Efficacy of high-dose chemotherapy and autologous stem cell transplantation in patients with relapsed medulloblastoma: a report on the Korean Society for Pediatric Neuro-Oncology (KSPNO)-S-053 study.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, JE | - |
dc.contributor.author | Kang, J | - |
dc.contributor.author | Yoo, KH | - |
dc.contributor.author | Sung, KW | - |
dc.contributor.author | Koo, HH | - |
dc.contributor.author | Lim, DH | - |
dc.contributor.author | Shin, HJ | - |
dc.contributor.author | Kang, HJ | - |
dc.contributor.author | Park, KD | - |
dc.contributor.author | Shin, HY | - |
dc.contributor.author | Kim, IH | - |
dc.contributor.author | Cho, BK | - |
dc.contributor.author | Im, HJ | - |
dc.contributor.author | Seo, JJ | - |
dc.contributor.author | Park, HJ | - |
dc.contributor.author | Park, BK | - |
dc.contributor.author | Ahn, HS | - |
dc.date.accessioned | 2011-05-19T05:15:03Z | - |
dc.date.available | 2011-05-19T05:15:03Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/2651 | - |
dc.description.abstract | The efficacy and toxicity of high-dose chemotherapy and autologous stem cell transplantation (HDCT/ASCT) were investigated for improving the outcomes of patients with relapsed medulloblastoma. A total of 15 patients with relapsed medulloblastoma were enrolled in the KSPNO-S-053 study from May 2005 to May 2007. All patients received approximately 4 cycles of salvage chemotherapy after relapse. Thirteen underwent HDCT/ASCT; CTE and CM regimen were employed for the first HDCT (HDCT1) and second HDCT (HDCT2), respectively, and 7 underwent HDCT2. One transplant related mortality (TRM) due to veno-occlusive disease (VOD) occurred during HDCT1 but HDCT2 was tolerable with no further TRM. The 3-yr overall survival probability and event-free survival rates +/-95% confidence intervals (CI) were 33.3+/-12.2% and 26.7% +/-11.4%, respectively. When analysis was confined to only patients who had a complete response (CR) or partial response (PR) prior to HDCT, the probability of 3-yr overall survival rates +/-95% CI was 40.0+/-15.5%. No patients with stable disease (SD) or progressive disease (PD) survived. Survival rates from protocol KSPNO-S-053 are encouraging and show that tumor status prior to HDCT/ASCT is an important factor to consider for improving survival rates of patients with relapsed medulloblastoma. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Cerebellar Neoplasms | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hematopoietic Stem Cell Transplantation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Medulloblastoma | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Salvage Therapy | - |
dc.subject.MESH | Transplantation, Autologous | - |
dc.subject.MESH | Young Adult | - |
dc.title | Efficacy of high-dose chemotherapy and autologous stem cell transplantation in patients with relapsed medulloblastoma: a report on the Korean Society for Pediatric Neuro-Oncology (KSPNO)-S-053 study. | - |
dc.type | Article | - |
dc.identifier.pmid | 20676326 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908784/ | - |
dc.contributor.affiliatedAuthor | 박, 준은 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.3346/jkms.2010.25.8.1160 | - |
dc.citation.title | Journal of Korean medical science | - |
dc.citation.volume | 25 | - |
dc.citation.number | 8 | - |
dc.citation.date | 2010 | - |
dc.citation.startPage | 1160 | - |
dc.citation.endPage | 1166 | - |
dc.identifier.bibliographicCitation | Journal of Korean medical science, 25(8). : 1160-1166, 2010 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.relation.journalid | J010118934 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.