Cited 0 times in Scipus Cited Count

Direct Oral Anticoagulant Dosing in Patients With Atrial Fibrillation: An Asian Perspective

Chao, TF | Chan, NY | Chan, YH | Cho, MS | Krittayaphong, R | Lee, KN  | Liu, S | Ngamukos, T | Tse, HF
JACC. Asia, 3(5). : 707-723, 2023
Journal Title
JACC. Asia
Optimal dosing of direct oral anticoagulants (DOACs) for stroke prevention in “gray area” patients with atrial fibrillation (AF) remains a challenge for clinicians. In Asia, this is concerning in patients who are very elderly, have low body weight, and are at a high risk of bleeding. This review aims to summarize the dose reduction criteria for DOACs, discuss the evidence on dosing of DOACs across Asian regions, and collate opinions from authors across Asia. Nonrecommended dosing of DOACs is common in Asia, primarily due to the fear of bleeding, with the total clinical benefit of higher dosing being overlooked. The ELDERCARE-AF (Edoxaban Low-Dose for Elder Care-Atrial Fibrillation Patients) trial and real-world case studies provide some evidence on the use of low-dose DOACs in gray area patients. Opinions on dose adjustment guidance, concomitant medication adjustments, and therapeutic drug monitoring were collated. Research is needed to fill the evidence gaps on optimal DOAC doses for gray area patients.

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
Ajou Authors
이, 광노
Full Text Link
Files in This Item:


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.