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Ischemic stroke in cancer patients with and without conventional mechanisms: a multicenter study in Korea.

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dc.contributor.authorKim, SG-
dc.contributor.authorHong, JM-
dc.contributor.authorKim, HY-
dc.contributor.authorLee, J-
dc.contributor.authorChung, PW-
dc.contributor.authorPark, KY-
dc.contributor.authorKim, GM-
dc.contributor.authorLee, KH-
dc.contributor.authorChung, CS-
dc.contributor.authorBang, OY-
dc.date.accessioned2011-05-20T04:53:59Z-
dc.date.available2011-05-20T04:53:59Z-
dc.date.issued2010-
dc.identifier.issn0039-2499-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2664-
dc.description.abstractBACKGROUND AND METHODS: To assess the precise mechanisms of stroke in cancer patients, we analyzed the data for cancer patients with acute ischemic stroke registered from 6 centers in South Korea. Clinical features, risk factors, diffusion-weighted imaging lesion patterns, and laboratory findings including D-dimer levels were compared between patients with conventional stroke mechanisms (CSMs) and cryptogenic group.



RESULTS: A total of 161 patients were included in this study: 97 (60.2%) patients in the CSM group and 64 (39.8%) in the cryptogenic group. Patients in the CSM group were older and vascular risk factors were more prevalent than in the cryptogenic group. Diffusion-weighted imaging patterns of multiple lesions involving multiple arterial territories were observed more frequently in the cryptogenic group than in the CSM group. In addition, levels of the D-dimer were higher in the cryptogenic group than in the CSM group (11.5+/-14.6 versus 3.6+/-10.3 microg/dL). In multivariate analysis, the diffusion-weighted imaging lesion pattern of multiple vascular territories (odds ratio, 11.2; 95% CI, 3.74 to 33.3), and D-dimer levels of >1.11 microg/dL (odds ratio, 10.6; 95% CI, 3.29 to 33.8) were associated independently with the cryptogenic group.



CONCLUSIONS: Stroke outside of CSM occurred in a large number in cancer patients. In stroke patients with cancer, d-dimer levels and diffusion-weighted imaging lesion patterns may be helpful in early identification of non-CSMs (especially coagulopathy associated with cancer) and possibly in guiding preventive strategies for stroke.
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dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHBrain Ischemia-
dc.subject.MESHCerebrovascular Circulation-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasms-
dc.subject.MESHProspective Studies-
dc.subject.MESHRegistries-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHStroke-
dc.titleIschemic stroke in cancer patients with and without conventional mechanisms: a multicenter study in Korea.-
dc.typeArticle-
dc.identifier.pmid20150545-
dc.identifier.urlhttp://stroke.ahajournals.org/cgi/pmidlookup?view=long&pmid=20150545-
dc.contributor.affiliatedAuthor홍, 지만-
dc.type.localJournal Papers-
dc.identifier.doi10.1161/STROKEAHA.109.571356-
dc.citation.titleStroke-
dc.citation.volume41-
dc.citation.number4-
dc.citation.date2010-
dc.citation.startPage798-
dc.citation.endPage801-
dc.identifier.bibliographicCitationStroke, 41(4). : 798-801, 2010-
dc.identifier.eissn1524-4628-
dc.relation.journalidJ000392499-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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