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Effects of atypical antipsychotic drugs on body weight and food intake in dopamine D2 receptor knockout mice.

Authors
Yoon, S; Noh, JS; Choi, SY; Baik, JH
Citation
Biochemical and biophysical research communications, 393(2):235-241, 2010
Journal Title
Biochemical and biophysical research communications
ISSN
0006-291X1090-2104
Abstract
Many atypical antipsychotic drugs cause weight gain, but the mechanism of this weight gain is unclear. To dissect the role of the dopamine D2 receptor (D2R), an important receptor in the pharmacology of antipsychotic drugs, we analyzed the effect of olanzapine, risperidone, and ziprasidone on changes in body weight and food intake in male wild-type (WT) and D2R knockout (D2R(-/-)) mice. The oral delivery of atypical antipsychotics, olanzapine (5 and 10mg/kg), risperidone (0.1 and 1.0mg/kg) and ziprasidone (10 and 20mg/kg) in both strains mice for 2 weeks suppressed body weight gain, except for olanzapine treatment in D2R(-/-) mice. Olanzapine treatment suppressed body weight gain and decreased food intake in WT mice, but also reduced fat body mass and locomotor activity, whereas D2R(-/-) mice did not show these changes. Ziprasidone and risperidone treatment produced similar responses in WT and D2R(-/-) mice. These data suggest the involvement of D2R in the effect of olanzapine on metabolic regulation. Further studies are required to explore the implications of D2R activity in antipsychotic-mediated metabolic complications.
MeSH terms
Adipose Tissue/drug effectsAnimalsAntipsychotic Agents/administration & dosageAntipsychotic Agents/adverse effects*Benzodiazepines/administration & dosageBenzodiazepines/adverse effects*Body Weight/drug effects*Eating/drug effects*MaleMiceMice, KnockoutMotor Activity/drug effectsPiperazines/administration & dosagePiperazines/adverse effectsReceptors, Dopamine D2/geneticsReceptors, Dopamine D2/physiology*Risperidone/administration & dosageRisperidone/adverse effectsThiazoles/administration & dosageThiazoles/adverse effectsWeight Gain*
DOI
10.1016/j.bbrc.2010.01.108
PMID
20117094
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
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