Kim, YC; Do, JE; Bang, D; Cho, BK; Cho, KH; Choi, JC; Kim, MB; Kim, MH; Kim, SY; Kim, SN; Lee, JH; Lee, SJ; Shin, DH; Shin, JH; Son, SJ; Suh, KS; Yoon, TY; Park, CK
Clinical and experimental dermatology, 35(2):135-139, 2010
Clinical and experimental dermatology
BACKGROUND: Spitz naevi have not been widely studied in Asians.
AIM: To compare the epidemiology and clinicopathological features of Spitz naevi in Koreans with lesions in western countries.
METHODS: In total, 80 Spitz naevi in 77 patients diagnosed over 10 years at 17 university hospitals in Korea were analysed.
RESULTS: The relative incidence of Spitz naevus vs. MM was 1 vs. 10.9. In most patients (75%) the Spitz naevi had been present for > 6 months. The size of the lesion was relatively large. Histologically, most of the lesions (54%) were the dermal type and pigmentation was common (49% of lesions). Immunohistochemical study found that all of the 34 lesions were positive for S-100 protein but only 14 (47%) were positive for HMB-45.
CONCLUSION: Spitz naevus is rare in Korea. The lesions were more commonly larger, pigmented, and of the dermal type than reported in western countries.
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