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Cancer-associated fibroblasts induce accumulation of SPP1+ macrophages to suppress tumor immunity of gastric cancers
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 허, 훈 | - |
| dc.contributor.author | 최, 준용 | - |
| dc.date.accessioned | 2023-11-16T05:43:57Z | - |
| dc.date.available | 2023-11-16T05:43:57Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/26856 | - |
| dc.language.iso | en | - |
| dc.title | Cancer-associated fibroblasts induce accumulation of SPP1+ macrophages to suppress tumor immunity of gastric cancers | - |
| dc.title.alternative | 위암 관련 섬유모세포와 SPP1 양성 대식세포가 면역치료에 미치는 영향에 대한 연구 | - |
| dc.type | Thesis | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000032495 | - |
| dc.subject.keyword | Gastric Cancer | - |
| dc.subject.keyword | Cancer-associated fibroblast | - |
| dc.subject.keyword | SPP1 | - |
| dc.subject.keyword | Macrophage | - |
| dc.subject.keyword | Tumor immunity | - |
| dc.description.degree | Master | - |
| dc.contributor.department | 대학원 의생명과학과 | - |
| dc.contributor.affiliatedAuthor | 최, 준용 | - |
| dc.date.awarded | 2023 | - |
| dc.type.local | Theses | - |
| dc.citation.date | 2023 | - |
| dc.embargo.liftdate | 9999-12-31 | - |
| dc.embargo.terms | 9999-12-31 | - |
| dc.description.tableOfContents | 1. Introduction 1
2. Material and Methods 3 3. Results 12 3.1 CAF-induced CCL2 contributes to the migration of monocytes 12 3.2 CAFs reprogram macrophages into the SPP1+ phenotype via the IL6/STAT3 signaling pathway 17 3.3 CAF-stimulated macrophages suppress T cell activation 24 3.4 Fibroblasts accumulate SPP1+ macrophages and control tumor immunity in a preclinical model 28 3.5 CAFs and SPP1+ macrophages are positively correlated in tumor infiltration and associated with clinical outcome in GC 35 4. Discussion 45 5. Reference 46 6. 국문요약 51 | - |
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- Theses > Graduate School of Biomedical Sciences > Master
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