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Identification and in silico pathway analysis of the differentially expressed genes in bone marrow and adipose tissues of Cotl1 knockout mice
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 정, 선용 | - |
| dc.contributor.author | 김, 도완 | - |
| dc.date.accessioned | 2023-11-16T05:44:00Z | - |
| dc.date.available | 2023-11-16T05:44:00Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/26870 | - |
| dc.language.iso | en | - |
| dc.title | Identification and in silico pathway analysis of the differentially expressed genes in bone marrow and adipose tissues of Cotl1 knockout mice | - |
| dc.title.alternative | Cotl1 유전자 제거 마우스의 골수 및 지방 조직에서의 차등 발현 유전자 발굴 및 in silico 경로 분석 | - |
| dc.type | Thesis | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000032741 | - |
| dc.subject.keyword | Cotl1 gene | - |
| dc.subject.keyword | COTL1 | - |
| dc.subject.keyword | Actin-binding protein | - |
| dc.subject.keyword | Cotl1 knock-out mouse | - |
| dc.subject.keyword | Differentially expressed gene | - |
| dc.subject.keyword | In silico pathway | - |
| dc.subject.keyword | Cotl1 유전자 | - |
| dc.subject.keyword | 액틴 결합 단백질 | - |
| dc.subject.keyword | Cotl1 유전자 제거 마우스 | - |
| dc.subject.keyword | 차등 발현 유전자 | - |
| dc.subject.keyword | In silico 경로 분석 | - |
| dc.description.degree | Doctor | - |
| dc.contributor.department | 대학원 의학과 | - |
| dc.contributor.affiliatedAuthor | 김, 도완 | - |
| dc.date.awarded | 2023 | - |
| dc.type.local | Theses | - |
| dc.citation.date | 2023 | - |
| dc.embargo.liftdate | 9999-12-31 | - |
| dc.embargo.terms | 9999-12-31 | - |
| dc.description.tableOfContents | I. INTRODUCTION 1
II. MATERIALS AND METHODS 8 A. Animals 8 B. RNA isolation and next-generation RNA-sequencing 8 C. Gene mapping and identification of differentially expressed genes 9 D. Disease and biological function analysis 10 E. Pathway analysis 10 F. RNA isolation and quantitative reverse-transcription PCR 12 G. Examination of mouse bone and adipose tissue phenotypes 13 III. RESULTS 15 A. Identification of DEG profiles 15 B. Disease and biological function analyses of the bone marrow and adipose tissues 17 C. Pathway analysis of actin-related biological functions in the bone marrow and adipose tissues of WT and Cotl1-/- mice 19 C-1. Formation of actin filaments 19 C-2. Organization of actin cytoskeleton 22 C-3. Common gene network analysis of actin-related biological functions between the bone marrow and adipose tissue DEG sets 25 D. Pathway analysis of bone-related diseases and biological functions of the bone marrow and adipose tissues in WT and Cotl1-/- mice 27 D-1. Remodeling of bone 27 D-2. Differentiation of osteoblasts and osteoclasts 30 D-3. Ossification 34 D-4. Metabolic bone disease 37 D-5. Common gene network analysis of bone-related diseases and biological functions between the bone marrow and adipose tissue DEG sets 40 E. Pathway analysis of lipid-related diseases and biological functions in the adipose tissues and bone marrow cells of the WT and Cotl1-/- mice 42 E-1. Adipogenesis 42 E-2. Differentiation of adipocytes 45 E-3. Metabolism of lipid 48 E-4. Disorder of lipid metabolism 51 E-5. Common gene network analysis of lipid-related diseases and biological functions between the adipose tissue and bone marrow DEG sets 54 F. Core-gene network analysis of actin-, bone-, and lipid-related diseases and biological functions in the bone marrow and adipose tissues in WT and Cotl1-/- mice 56 G. Evaluation of the mRNA expression levels of core genes using in silico pathway analysis 58 H. Bone and adipose tissue phenotypes of mice 61 IV. DISCUSSION 63 V. CONCLUSION 72 REFERENCES 73 국문요약 88 | - |
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