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The Role of Jak3 in Skin Wound Healing
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 조, 원태 | - |
| dc.date.accessioned | 2023-11-16T05:44:00Z | - |
| dc.date.available | 2023-11-16T05:44:00Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/26871 | - |
| dc.language.iso | en | - |
| dc.title | The Role of Jak3 in Skin Wound Healing | - |
| dc.title.alternative | 피부 상처 치유에서 Jak3의 역할 | - |
| dc.type | Thesis | - |
| dc.identifier.url | http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000032927 | - |
| dc.subject.keyword | Jak3 | - |
| dc.subject.keyword | skin | - |
| dc.subject.keyword | skin wound healing model | - |
| dc.subject.keyword | fibroblast | - |
| dc.subject.keyword | sebaceous gland | - |
| dc.subject.keyword | 피부 | - |
| dc.subject.keyword | 피부 상처 치유 모델 | - |
| dc.subject.keyword | 섬유아세포 | - |
| dc.subject.keyword | 피지선 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | 대학원 의학과 | - |
| dc.contributor.affiliatedAuthor | 조, 원태 | - |
| dc.date.awarded | 2023 | - |
| dc.type.local | Theses | - |
| dc.citation.date | 2023 | - |
| dc.embargo.liftdate | 9999-12-31 | - |
| dc.embargo.terms | 9999-12-31 | - |
| dc.description.tableOfContents | I. INTRODUCTION 1
II. MATERIALS AND METHODS 6 A. Animals 6 B. Skin wound healing model 6 C. Drug treatment (in vivo) 8 D. Cryostat section 8 E. H&E stain 8 F. Immunohistochemistry 9 G. Primary sebocyte culture 9 H. Primary skin fibroblast culture 10 I. Wound healing assay 10 J. MTT assay 11 K. Drug treatment (in vitro) 11 L. Oil red O stain 11 M. Immunocytochemistry 12 N. Western blot 12 O. Statistical analysis 12 III. RESULTS 14 A. Reduction of skin contraction by Jak3 inhibition 14 B. Effect of Jak3 inhibitor on the DMSO-induced contraction 16 C. Reduction of epidermis thickness by Jak3 inhibition 19 D. Reduction of hypodermic muscle thickness by Jak3 inhibition 21 E. Decrease of MMPs, results of α-SMA and vimentin in western blot 23 F. Decrease of cell proliferation using MTT assay 25 G. Reduced migration of fibroblasts by Jak3 inhibition 27 H. Sebaceous gland in the hair follicle stained by isolectin B4 30 I. Decrease in the area of sebocyte and the volume of sebaceous gland stained by isolectin B4 32 J. Decreased the size of primary cultured sebaceous glands by Jak3 inhibition 34 IV. DISCUSSION 36 V. REFERENCES 39 | - |
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