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Clinical/pathological analysis of gallbladder adenomyomatosis; type and pathogenesis

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dc.contributor.authorKim, JH-
dc.contributor.authorJeong, IH-
dc.contributor.authorHan, JH-
dc.contributor.authorKim, JH-
dc.contributor.authorHwang, JC-
dc.contributor.authorYoo, BM-
dc.contributor.authorKim, JH-
dc.contributor.authorKim, MW-
dc.contributor.authorKim, WH-
dc.date.accessioned2011-05-30T05:27:17Z-
dc.date.available2011-05-30T05:27:17Z-
dc.date.issued2010-
dc.identifier.issn0172-6390-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2711-
dc.description.abstractBACKGROUND/AIMS: The aim of this study was to analyze the clinical/pathological outcomes of patients that underwent surgery for gallbladder adenomyomatosis, to clarify the characteristics of the type and pathogenesis of adenomyomatosis.



METHODOLOGY: From May 1997 to March 2008, 4704 consecutive patients underwent cholecystectomy at Ajou University Medical Center. Among them, 113 (2.4%) patients that were histopathologically diagnosed with adenomyomatosis or adenomatous hyperplasia were selected for this study. The patients were divided into a fundal type group and a segmental/diffuse type group, and the specimens reviewed with Hematoxylin-Eosin (H & E) and immunohistochemical stainings.



RESULTS: Sixty-three patients were male and 50 female; the age ranged from 17 to 76 years of age. The fundal type was the most common type. Gallstones were present in 69.9% of the patients. In the analysis of the fundal and segmental/diffuse types, gallstones were present in 23 patients with fundal type and in 53 patients with segmental/diffuse type; this difference was statistically significant (p < 0.05). Review of H & E staining showed that the most common findings were grade 1 (n = 14) in the fundal type and grade 2 (n = 23) in the segmental/diffuse type; there was a significant difference in the inflammatory grade (p < 0.05). Immunohistochemical staining showed expression of vimentin, as a mesenchymal marker in 28.0% of cases (n = 16).



CONCLUSIONS: The fundal type differed from the segmental/diffuse type based on the clinical/ pathological features; it had a lower frequency of gallstones and a lower inflammatory grade. In addition, no cancer was identified in the resected gallbladders of patients with adenomyomatosis. The findings suggest that the Rokitansky-Aschoff sinuses (RAS) were associated with acquired motility, based on the expression of vimentin, consistent with an epithelial-mesenchymal transition.
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dc.language.isoen-
dc.subject.MESHAdenomyoma-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHEpithelial Cells-
dc.subject.MESHFemale-
dc.subject.MESHGallbladder Neoplasms-
dc.subject.MESHGallstones-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMesoderm-
dc.subject.MESHMiddle Aged-
dc.titleClinical/pathological analysis of gallbladder adenomyomatosis; type and pathogenesis-
dc.typeArticle-
dc.identifier.pmid20698201-
dc.contributor.affiliatedAuthor김, 지훈-
dc.contributor.affiliatedAuthor한, 재호-
dc.contributor.affiliatedAuthor김, 장희-
dc.contributor.affiliatedAuthor황, 재철-
dc.contributor.affiliatedAuthor유, 병무-
dc.contributor.affiliatedAuthor김, 진홍-
dc.contributor.affiliatedAuthor김, 명욱-
dc.contributor.affiliatedAuthor김, 욱환-
dc.type.localJournal Papers-
dc.citation.titleHepato-gastroenterology-
dc.citation.volume57-
dc.citation.number99-100-
dc.citation.date2010-
dc.citation.startPage420-
dc.citation.endPage425-
dc.identifier.bibliographicCitationHepato-gastroenterology, 57(99-100). : 420-425, 2010-
dc.relation.journalidJ001726390-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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