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Differential cytoprotective effect of copper- and iron-containing chlorophyllins against oxidative stress-mediated cell death.

Authors
Yu, JW; Yang, R; Kim, YS
Citation
Free radical research, 44(6):655-667, 2010
Journal Title
Free radical research
ISSN
1071-57621029-2470
Abstract
Chlorophyllin (CHL), a copper-containing chlorophyll derivative, was previously reported to possess reactive oxygen species (ROS) scavenging activity. However, the antioxidant property of iron-containing chlorophyllin, iron chlorin e6 (FeCe6), has not been explored in detail. This study systematically investigated the antioxidant capacity of two chlorophyllins, CHL and FeCe6, and their cytoprotective effects against ROS toxicity in human Jurkat T-cells. Both CHL and FeCe6 exhibited a wide range of antioxidant activities to ABTS radical, singlet oxygen, peroxynitrite, and peroxyl radical. Notably, FeCe6 exerted a significant suppressive effect on hydrogen peroxide-dependent cytotoxicity and apoptosis in Jurkat T-cells, while negligible or much weaker inhibition was observed by CHL. This differential cytoprotective effect is likely due to the different hydrogen peroxide scavenging capacity of two chlorophyllins. Moreover, FeCe6 attenuated menadione-induced cell death and tumour necrosis factor (TNF)-alpha-induced IkappaB phosphorylation via scavenging of intracellular ROS. Taken together, the results suggest that FeCe6 is a promising cytoprotective antioxidant against oxidative stress-mediated cellular toxicity.
MeSH terms
Antioxidants/*pharmacologyApoptosis/*drug effectsChlorophyllides/*pharmacologyFree Radical Scavengers/pharmacologyHumansJurkat CellsMetalloporphyrins/*pharmacologyOxidative Stress/*drug effectsReactive Oxygen Species/metabolism
DOI
10.3109/10715761003733893
PMID
20370562
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
AJOU Authors
김, 유선
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