261 284

Cited 142 times in

Distinct roles of rodent orbitofrontal and medial prefrontal cortex in decision making.

Authors
Sul, JH; Kim, H; Huh, N; Lee, D; Jung, MW
Citation
Neuron, 66(3):449-460, 2010
Journal Title
Neuron
ISSN
0896-62731097-4199
Abstract
We investigated how different subregions of rodent prefrontal cortex contribute to value-based decision making, by comparing neural signals related to animal's choice, its outcome, and action value in orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC) of rats performing a dynamic two-armed bandit task. Neural signals for upcoming action selection arose in the mPFC, including the anterior cingulate cortex, only immediately before the behavioral manifestation of animal's choice, suggesting that rodent prefrontal cortex is not involved in advanced action planning. Both OFC and mPFC conveyed signals related to the animal's past choices and their outcomes over multiple trials, but neural signals for chosen value and reward prediction error were more prevalent in the OFC. Our results suggest that rodent OFC and mPFC serve distinct roles in value-based decision making and that the OFC plays a prominent role in updating the values of outcomes expected from chosen actions.
MeSH terms
Action Potentials/*physiologyAnimalsBehavior, Animal/physiologyCuesDecision Making/*physiologyElectrophysiologyFrontal Lobe/*physiologyGyrus Cinguli/physiologyMaleModels, NeurologicalModels, PsychologicalMotor Activity/physiologyNeurons/*physiologyPsychomotor Performance/physiologyRatsRats, Sprague-DawleyRegression AnalysisReinforcement (Psychology)
DOI
10.1016/j.neuron.2010.03.033
PMID
20471357
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
정, 민환
Full Text Link
Files in This Item:
449-460.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse