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Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy.

Authors
Paik, MJ; Ahn, YH; Lee, PH; Kang, H; Park, CB; Choi, S; Lee, G
Citation
Clinica chimica acta: international journal of clinical chemistry, 411(19-20):1532-1535, 2010
Journal Title
Clinica chimica acta: international journal of clinical chemistry
ISSN
0009-89811873-3492
Abstract
BACKGROUND: Polyamines (PAs) are important modulators of physiological condition, and are associated with neurodegenerative disease. Thus, we investigated the change of PA concentration in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA).



METHODS: CSF samples from patients with PD and MSA were examined by gas chromatography-mass spectrometry in selected ion monitoring mode using N-ethoxycarbonyl/N-pentafluoropropyonyl derivatives.



RESULTS: PA concentrations were significantly different in patients with PD and MSA compared with those in the normal group. In the PD group, as compared with the MSA group, concentrations of putrescine, N(1)-acetylspermidine, and putrescine spermidine(-)(1) were significantly increased, whereas the concentration of spermidine was significantly reduced.



CONCLUSIONS: These results could be helpful for understanding the complexity of biochemical events in patients with PD and MSA, and may serve as metabolic markers for diagnosis of PD and MSA.
MeSH terms
AgedBiological Markers/analysisCerebrospinal Fluid/*chemistryFemaleGas Chromatography-Mass SpectrometryHumansMaleMultiple System Atrophy/*diagnosisParkinson Disease/*diagnosisPolyamines/*analysisPutrescine/analysisSpermidine/analogs & derivatives/analysis
DOI
10.1016/j.cca.2010.05.034
PMID
20515677
Appears in Collections:
Journal Papers > Research Organization > Institute for Neuroregeneration & Stem Cell Research
Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
백, 만정안, 영환박, 찬배이, 광
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