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Implantation of polymer scaffolds seeded with neural stem cells in a canine spinal cord injury model.

Authors
Kim, BG; Kang, YM; Phi, JH; Kim, YH; Hwang, DH; Choi, JY; Ryu, S; Elastal, AE; Paek, SH; Wang, KC; Lee, SH; Kim, SU; Yoon, BW
Citation
Cytotherapy, 12(6):841-845, 2010
Journal Title
Cytotherapy
ISSN
1465-32491477-2566
Abstract
BACKGROUND AIMS: Combinatorial approaches employing diverse therapeutic modalities are required for clinically relevant repair of injured spinal cord in human patients. Before translation into the clinic, the feasibility and therapeutic potential of such combinatorial strategies in larger animal species need to be examined.



METHODS: The present study tested the feasibility of implanting polymer scaffolds via neural stem cell (NSC) delivery in a canine spinal cord injury (SCI) model. The poly(lactic-co-glycolic acid) (PLGA) scaffolds seeded with human NSC were implanted into hemisected canine spinal cord.



RESULTS: The PLGA scaffolds bridged tissue defects and were nicely integrated with residual canine spinal cord tissue. Grafted NSC survived the implantation procedure and showed migratory behavior to residual spinal cord tissue. Ectopic expression of a therapeutic neurotrophin-3 gene was also possible in NSC seeded within the PLGA scaffolds.



CONCLUSIONS: Our description of a canine SCI model would be a valuable resource for pre-clinical trials of combinatorial strategies in larger animal models.
MeSH terms
AnimalsBiocompatible Materials/chemistry/metabolismCell MovementDisease Models, AnimalDogsFeasibility StudiesGraft SurvivalHumansLactic Acid/chemistry/metabolismNeural Stem Cells/*metabolism/pathology/*transplantationNeurotrophin 3/genetics/metabolismPolyglycolic Acid/chemistry/metabolismSpinal Cord/metabolism/pathologySpinal Cord Injuries/pathology/*therapy*Stem Cell TransplantationTissue EngineeringTissue Scaffolds/chemistry/*utilizationTransplantation, Heterologous
DOI
10.3109/14653249.2010.501784
PMID
20629485
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Brain Science
AJOU Authors
김, 병곤
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