43 367

Cited 12 times in

Acute myeloid leukemia with t(16;21)(q24;q22) and eosinophilia: case report and review of the literature.

Authors
Park, IJ; Park, JE; Kim, HJ; Jung, HJ; Lee, WG; Cho, SR
Citation
Cancer genetics and cytogenetics, 196(1):105-108, 2010
Journal Title
Cancer genetics and cytogenetics
ISSN
0165-46081873-4456
Abstract
The t(16;21)(q24;q22), a rare chromosomal translocation involving chromosome 21 in de novo and therapy-related acute myeloid leukemia (AML), produces a RUNX1-CBFA2T3 fusion gene (previously AML1-MTG16) fusion gene. The translocation has been reported in 20 patients with AML, with eosinophilia present in 3 cases. Here we report a pediatric case of t(16;21)(q24;q22) in de novo AML with eosinophilia and suggest that eosinophilia is a hematologic characteristic of at least a subpopulation of AML with t(16;21)(q24;q22). A 4-year-old Korean girl was admitted with complaints of pale appearance and dizziness, and was diagnosed with acute myelomonocytic leukemia. On admission, laboratory evaluation revealed hemoglobin at 3.3 g/dL, platelets at 9.0 x 10(9)/L, and white blood cells at 9.1 x 10(9)/L with 10% eosinophils and 1% blasts. The bone marrow aspirate contained 31% blasts and 11% eosinophils. Flow cytometric analysis revealed the expression of CD13, CD14, CD19, CD33, CD34, and HLA-DR by the leukemic blasts. The karyotype was 47,XX, + 8,t(16;21)(q24;q22)[18]/46,XX[2]. Interphase fluorescence in situ hybridization analysis with a dual-color, dual-fusion translocation LSI AML1/ETO probe set for RUNX1 and RUNX1T1 produced three signals for each probe in 90% of interphases, but no fusion signals. We confirmed the presence of RUNX1-CBFA2T3 fusion transcripts with reverse transcriptase-polymerase chain reaction, using primers AML1ex5f1 and MTG16r2.
MeSH terms
Child, Preschool*Chromosomes, Human, Pair 16*Chromosomes, Human, Pair 21FemaleHumansIn Situ Hybridization, FluorescenceKaryotypingLeukemia, Myeloid, AcuteReverse Transcriptase Polymerase Chain Reaction*Translocation, Genetic
DOI
10.1016/j.cancergencyto.2009.08.017
PMID
19963144
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Genetics
AJOU Authors
박, 일중박, 준은김, 현주이, 위교조, 성란
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse