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Usefulness of delta value of platelet parameters on ADVIA 120 for the functional reactivity of stored platelets.

Authors
Park, IJ; Lim, YA; Cho, SR
Citation
Journal of clinical laboratory analysis, 24(1):38-43, 2010
Journal Title
Journal of clinical laboratory analysis
ISSN
0887-80131098-2825
Abstract
An agonist-induced expression of CD62P by flow cytometry analysis for evaluating platelet functional reactivity has some disadvantages. We investigated the usefulness of platelet parameters by ADVIA 120 to predict an agonist-induced expression of CD62P in stored platelets. The CD62P expression by flow cytometry and the platelet parameters by ADVIA 120 were studied in samples from 27 platelet pheresis products. Delta (Delta) values were calculated as the degree of change of the platelet parameters studied with or without adenosine 5'-diphosphate sodium (ADP) stimulation. The CD62P expression of the ADP-activated platelets were correlated with the Delta platelet count (r=0.517) in the short-term storage group (within 10 hr from preparation), with the platelet component distribution width (PCDW) without ADP (r=-0.744) and the DeltaPCDW (r=-0.755) in the long-term storage group (after 10 hr from preparation). Therefore, the delta values of platelet parameters on ADVIA 120 analysis in platelets between with and without ADP stimulation could be useful as a simple predictor for the functional reactivity of stored platelets.
MeSH terms
Adenosine Diphosphate/pharmacologyBlood Platelets/cytology/drug effects/*physiologyFlow Cytometry/instrumentation/methodsHematologic Tests/instrumentation/methodsHumansP-Selectin/biosynthesis/*bloodStatistics, Nonparametric
DOI
10.1002/jcla.20364
PMID
20087952
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
AJOU Authors
박, 일중임, 영애조, 성란
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