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Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: emergence of a novel OXA-182.

DC Field Value Language
dc.contributor.authorKim, CK-
dc.contributor.authorLee, Y-
dc.contributor.authorLee, H-
dc.contributor.authorWoo, GJ-
dc.contributor.authorSong, W-
dc.contributor.authorKim, MN-
dc.contributor.authorLee, WG-
dc.contributor.authorJeong, SH-
dc.contributor.authorLee, K-
dc.contributor.authorChong, Y-
dc.date.accessioned2011-06-01T05:23:50Z-
dc.date.available2011-06-01T05:23:50Z-
dc.date.issued2010-
dc.identifier.issn0732-8893-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2781-
dc.description.abstractIncrease in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-β-lactamase (MBL)-producing isolates. bla(OXA)-₂₃-like and ISAba1-asssociated bla(OXA)-₅₁-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel bla(OXA)-₁₈₂ was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumanniiAcinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with bla(OXA)-₂₃-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.-
dc.language.isoen-
dc.subject.MESHAcinetobacter/classification/drug effects/*enzymology/isolation & purification-
dc.subject.MESHAcinetobacter Infections/*epidemiology/microbiology-
dc.subject.MESHAmino Acid Sequence-
dc.subject.MESHAnti-Bacterial Agents/*pharmacology-
dc.subject.MESHBacterial Proteins/biosynthesis/chemistry/classification/*genetics-
dc.subject.MESHDNA, Bacterial/analysis/genetics-
dc.subject.MESHDrug Resistance, Bacterial/*genetics-
dc.subject.MESHGenetic Variation-
dc.subject.MESHHumans-
dc.subject.MESHImipenem/*pharmacology-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHPolymerase Chain Reaction/methods-
dc.subject.MESHPrevalence-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSpecies Specificity-
dc.subject.MESHbeta-Lactamases/biosynthesis/chemistry/classification/*genetics-
dc.titlePrevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: emergence of a novel OXA-182.-
dc.typeArticle-
dc.identifier.pmid20884158-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0732-8893(10)00288-9-
dc.contributor.affiliatedAuthor이, 위교-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.diagmicrobio.2010.07.014-
dc.citation.titleDiagnostic microbiology and infectious disease-
dc.citation.volume68-
dc.citation.number4-
dc.citation.date2010-
dc.citation.startPage432-
dc.citation.endPage438-
dc.identifier.bibliographicCitationDiagnostic microbiology and infectious disease, 68(4):432-438, 2010-
dc.identifier.eissn1879-0070-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
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