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A biodegradable, injectable, gel system based on MPEG-b-(PCL-ran-PLLA) diblock copolymers with an adjustable therapeutic window.

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dc.contributor.authorKang, YM-
dc.contributor.authorLee, SH-
dc.contributor.authorLee, JY-
dc.contributor.authorSon, JS-
dc.contributor.authorKim, BS-
dc.contributor.authorLee, B-
dc.contributor.authorChun, HJ-
dc.contributor.authorMin, BH-
dc.contributor.authorKim, JH-
dc.contributor.authorKim, MS-
dc.date.accessioned2011-06-01T05:42:59Z-
dc.date.available2011-06-01T05:42:59Z-
dc.date.issued2010-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2786-
dc.description.abstractIn situ-forming gel systems have drawn increasing attention for their potential use in a variety of biomedical applications. Here, we examined an in situ-forming gel system comprised of MPEG-b-PCL and MPEG-b-(PCL-ran-PLLA) diblock copolymers with different PLLA contents (0-10 mol%) in the PCL segment. The crystalline region of the PCL-ran-PLLA segment decreased with increasing PLLA content. The MPEG-b-(PCL-ran-PLLA) diblock copolymer solutions were liquid at room temperature and only MPEG-b-(PCL-ran-PLLA) diblock copolymer solutions with a PLLA content < or = 5 mol% in the PCL segment showed a sol-to-gel transition as the temperature was increased. The viscosity change associated with sol-to-gel phase transition depended on the PLLA content in the PCL segment. A MPEG-b-PCL diblock copolymer solution incubated in vitro showed increasing viscosity without degradation, whereas the viscosity of MPEG-b-(PCL-ran-PLLA) diblock copolymer solutions continuously and sharply decreased with increasing PLLA content in the PCL segment. As the amount of PLLA increased, the size of in vivo-formed MPEG-b-(PCL-ran-PLLA) gels after initial injection tended to gradually decrease because of hydrolytic degradation of the PLLA in the PCL-ran-PLLA segment. An immunohistochemical examination showed that in vivo MPEG-b-(PCL-ran-PLLA) diblock copolymer gels provoked only a modest inflammatory response. Collectively, our results show that the MPEG-b-(PCL-ran-PLLA) diblock copolymer gel described here could serve as a minimally invasive, therapeutic, in situ-forming gel system that offers an experimental window adjustable from a few weeks to a few months.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHBiocompatible Materials-
dc.subject.MESHChromatography, Gel-
dc.subject.MESHCrystallization-
dc.subject.MESHFluorescent Antibody Technique-
dc.subject.MESHGels-
dc.subject.MESHImplants, Experimental-
dc.subject.MESHInjections-
dc.subject.MESHLactic Acid-
dc.subject.MESHMagnetic Resonance Spectroscopy-
dc.subject.MESHPhase Transition-
dc.subject.MESHPolyesters-
dc.subject.MESHPolyethylene Glycols-
dc.subject.MESHPolymers-
dc.subject.MESHRats-
dc.subject.MESHSolutions-
dc.subject.MESHStaining and Labeling-
dc.subject.MESHTemperature-
dc.subject.MESHViscosity-
dc.subject.MESHWater-
dc.titleA biodegradable, injectable, gel system based on MPEG-b-(PCL-ran-PLLA) diblock copolymers with an adjustable therapeutic window.-
dc.typeArticle-
dc.identifier.pmid20022371-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0142-9612(09)01359-3-
dc.contributor.affiliatedAuthor민, 병현-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.biomaterials.2009.11.115-
dc.citation.titleBiomaterials-
dc.citation.volume31-
dc.citation.number9-
dc.citation.date2010-
dc.citation.startPage2453-
dc.citation.endPage2469-
dc.identifier.bibliographicCitationBiomaterials, 31(9). : 2453-2469, 2010-
dc.identifier.eissn1878-5905-
dc.relation.journalidJ001429612-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
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