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Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women.

Authors
Sherwood, A; Park, SB; Hughes, JW; Blumenthal, JA; Hinderliter, A; Trivedi, R; McFetridge-Durdle, J
Citation
Menopause (New York, N.Y.), 17(2):403-409, 2010
Journal Title
Menopause (New York, N.Y.)
ISSN
1072-37141530-0374
Abstract
OBJECTIVE: After menopause, women are at an increased risk of cardiovascular disease. The present study assessed cardiovascular hemodynamics in premenopausal versus postmenopausal women, with a focus on systemic vascular resistance (SVR) at rest and during stress. Sympathetic nervous system activity and cardiovascular adrenergic receptor (AR) function were also examined.

METHODS: A total of 90 women (45 premenopausal and 45 postmenopausal) completed a laboratory protocol composed of a resting baseline and four mental stress tasks. Measurements included blood pressure, cardiac output, SVR, and plasma catecholamine level. In addition, alpha- and beta-AR responsiveness to the infusion of selective pharmacological agonists was assessed.

RESULTS: Compared with premenopausal women, postmenopausal women were characterized by similar blood pressure but lower cardiac output and higher SVR, both at rest and during stress (Ps < 0.05). Postmenopausal women also had higher baseline plasma norepinephrine levels (P = 0.007) and reduced beta-AR responsiveness (P = 0.02), although differences in beta-AR responsiveness may have been confounded by aging effects.

CONCLUSIONS: After menopause, women exhibit altered sympathetic nervous system activity and a sustained increase in hemodynamic load that may contribute to pathological structural and functional changes in the heart and blood vessels.
MeSH terms
Blood PressureCardiac OutputCardiovascular System/*physiopathologyCatecholamines/bloodFemale*HemodynamicsHumansMiddle AgedPostmenopause/*physiologyPremenopause/*physiologyReceptors, Adrenergic/physiologyReceptors, Adrenergic, beta/physiologySympathetic Nervous System/*physiopathologyVascular Resistance/*physiology
DOI
10.1097/gme.0b013e3181b9b061
PMID
19770780
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Family Practice & Community Health
AJOU Authors
박, 샛별
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