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Relationship of synovial tumor necrosis factor alpha and interleukin 6 to temporomandibular disorder.

Authors
Lee, JK; Cho, YS; Song, SI
Citation
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 68(5):1064-1068, 2010
Journal Title
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
ISSN
0278-23911531-5053
Abstract
PURPOSE: The purpose of this study was to elucidate the relationship of tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) to temporomandibular disorder with clinical symptoms such as pain, joint sounds, and mouth opening limitation by analysis of the level of these molecules in the synovial fluid.



PATIENTS AND METHODS: Twenty-four patients with chief complaints of pain, mouth opening limitation, and clicking sounds were selected as the experimental group and compared with 5 healthy subjects. After joint lavage with arthrocentesis, diluted synovial fluid was collected and enzyme-linked immunosorbent assay was done for analysis of TNF-alpha and IL-6 in 24 experimental patients and 5 healthy subjects.



RESULTS: The synovial levels of TNF-alpha and IL-6 were elevated in the experimental group compared with the healthy control group, but no significant correlation was established. The synovial levels of TNF-alpha and IL-6 were elevated in the acute pain group compared with the chronic pain group, but no significant correlation was established.



CONCLUSION: In our analysis of 2 proinflammatory cytokines, TNF-alpha and IL-6, in the synovial fluid of temporomandibular disorder patients with symptoms of pain, mouth opening limitation, and clicking, both were elevated without statistical significance.
MeSH terms
Acute DiseaseBiological Markers/analysisChronic DiseaseEnzyme-Linked Immunosorbent AssayFacial Pain/immunology/physiopathologyHumansInflammation Mediators/analysisInterleukin-6/*analysisParacentesisRange of Motion, Articular/physiologySoundSynovial Fluid/*immunologyTemporomandibular Joint Disorders/*immunology/physiopathologyTherapeutic IrrigationTumor Necrosis Factor-alpha/*analysis
DOI
10.1016/j.joms.2009.08.007
PMID
20031289
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Journal Papers > School of Medicine / Graduate School of Medicine > Dentistry
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