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Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two Korean cohorts.

Authors
Hong, KW; Go, MJ; Jin, HS; Lim, JE; Lee, JY; Han, BG; Hwang, SY; Lee, SH; Park, HK; Cho, YS; Oh, B
Citation
Journal of human hypertension, 24(6):367-372, 2010
Journal Title
Journal of human hypertension
ISSN
0950-92401476-5527
Abstract
Blood pressure, one of the important vital signs, is affected by multiple genetic and environmental factors. Recently, several genome-wide association (GWA) studies have successfully identified genetic factors that influence blood pressure and hypertension risk. In this study, we report results of the Korean Association REsource (KARE, 8842 subjects) GWA study on blood pressure and hypertension risk. In all, 10 single-nucleotide polymorphisms (SNPs) that showed significant association with hypertension were further analysed for replication associations in the Health2 project (7861 subjects). Among these 10 SNPs, 3 were replicated in the Health2 cohort for an association with systolic or diastolic blood pressure. The most significant SNP (rs17249754 located in ATPase, Ca(++) transporting, plasma membrane 1 (ATP2B1)) has been previously reported, and the other two SNPs are rs1378942 in the c-src tyrosine kinase (CSK) gene and rs12945290 in the arylsulphatase G (ARSG) gene. An additional hypertension case-control study confirmed that rs17249754 (in ATP2B1) increases hypertension risk in both the KARE and Health2 (meta-analysis, P-value=4.25 x 10(-9)) cohorts. One more SNP, rs995322, located in the CUB and Sushi multiple domains 1 (CSMD1), is also associated with increased risk of hypertension (meta-analysis, P-value=1.00 x 10(-4)). Despite the difficulty of obtaining replication results for a complex trait genetic association between blood pressure and hypertension, we were able to identify consistent genetic factors in both the Korean cohorts in ATP2B1, CSK, ARSG and CSMD1 genes.
MeSH terms
AdultAgedArylsulfatases/*geneticsAsian Continental Ancestry Group/geneticsBlood Pressure/*geneticsBody Mass IndexCase-Control StudiesCohort StudiesFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansHypertension/epidemiology/*geneticsKorea/epidemiologyMaleMembrane Proteins/*geneticsMiddle AgedPlasma Membrane Calcium-Transporting ATPases/*geneticsPolymorphism, Single NucleotideProtein-Tyrosine Kinases/*geneticsProto-Oncogene Proteins/*geneticsRisk Factors
DOI
10.1038/jhh.2009.86
PMID
19960030
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Genetics
AJOU Authors
진, 현석
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