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The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women.

Authors
Tong, SY; Lee, JM; Song, ES; Lee, KB; Kim, MK; Yun, YM; Lee, JK; Son, SK; Lee, JP; Kim, JH; Hur, SY; Kwon, YI
Citation
Cancer causes & control : CCC, 21(1):23-30, 2010
Journal Title
Cancer causes & control : CCC
ISSN
0957-52431573-7225
Abstract
The purpose of the study was to investigate the association between cervical cancer risk and single-nucleotide polymorphisms (SNPs) in three one-carbon metabolism genes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) in Korean women. Twelve SNPs were identified in MTHFR, MTR, and MTRR in the 927 case-control samples, which included 165 cervical intraepithelial neoplasia 1 (CIN1), 167 cervical intraepithelial neoplasia 2 and 3 (CIN2/3), 155 cervical cancer patients, and 440 normal controls. The frequencies of the genotypes and haplotypes were assessed in the controls, CINs, and cervical cancers. Individual carriers of the variant allele C of MTHFR A1298C (rs1801131) had a 0.64-fold [95% confidence interval (CI): 0.42-0.98] decreased risk for CIN2/3 compared with common homozygotes. However, no significant association was found between most other variants and cervical cancer risk. The results also identified an increased CIN1 risk in carriers with at least one copy of haplotype 3 in the MTHFR gene (odds ratio, 1.88; 95% CI: 1.03-3.42). In conclusion, there was no significant association between most SNPs in MTHFR, MTR, or MTRR and the risk of CIN and cervical cancer in Korean women. In addition, there was no significant association of MTHFR haplotypes with risk of CIN2/3 and cervical cancer.
MeSH terms
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/*geneticsCase-Control StudiesCervical Intraepithelial Neoplasia/*geneticsFemaleFerredoxin-NADP Reductase/*geneticsGenetic Predisposition to DiseaseHaplotypesHumansKoreaMethylenetetrahydrofolate Reductase (NADPH2)/*genetics*Polymorphism, GeneticUterine Cervical Neoplasms/*genetics
DOI
10.1007/s10552-009-9430-z
PMID
19760026
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Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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