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In vivo efficacy of paclitaxel-loaded injectable in situ-forming gel against subcutaneous tumor growth.

Authors
Lee, JY; Kim, KS; Kang, YM; Kim, ES; Hwang, SJ; Lee, HB; Min, BH; Kim, JH; Kim, MS
Citation
International journal of pharmaceutics, 392(1-2):51-56, 2010
Journal Title
International journal of pharmaceutics
ISSN
0378-51731873-3476
Abstract
Injectable in situ-forming gels have received considerable attention as localized drug delivery systems. Here, we examined a poly(ethylene glycol)-b-polycaprolactone (MPEG-PCL) diblock copolymer gel as an injectable drug depot for paclitaxel (Ptx). The copolymer solution remained liquid at room temperature and rapidly gelled in vivo at body temperature. In vitro experiments showed that Ptx was released from MPEG-PCL copolymer gels over the course of more than 14 days. Experiments employing intratumoral injection of saline (control), gel-only, Taxol, or Ptx-loaded gel into mice bearing B16F10 tumor xenografts showed that Ptx-loaded gel inhibited the growth of B16F10 tumors more effectively than did saline or gel alone. Further, intratumoral injection of Ptx-loaded gel was more efficacious in inhibiting the growth of B16F10 tumor over 10 days than was injection of Taxol. A histological analysis demonstrated an increase in necrotic tissue in tumors treated with Ptx-loaded gel. In conclusion, our data show that intratumoral injection of Ptx-loaded MPEG-PCL diblock copolymer yielded an in situ-forming gel that exhibited controlled Ptx release profile, and that was effective in treating localized solid tumors.
MeSH terms
AnimalsAntineoplastic Agents, Phytogenic/administration & dosage*Antineoplastic Agents, Phytogenic/therapeutic useBiocompatible Materials/chemistryCell Line, TumorCell Survival/drug effectsDelayed-Action PreparationsDrug Carriers/chemistryDrug CompoundingDrug Delivery Systems/methods*GelsInjections, IntralesionalInjections, SubcutaneousMiceMice, HairlessNeoplasms, Experimental/drug therapy*Neoplasms, Experimental/pathologyPaclitaxel/administration & dosage*Paclitaxel/therapeutic usePolyesters/chemistryPolyethylene Glycols/chemistrySolubilityTemperatureViscosityXenograft Model Antitumor Assays
DOI
10.1016/j.ijpharm.2010.03.033
PMID
20298770
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
AJOU Authors
민, 병현
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