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Preparation and evaluation of fexofenadine microemulsions for intranasal delivery.

Authors
Piao, HM; Balakrishnan, P; Cho, HJ; Kim, H; Kim, YS; Chung, SJ; Shim, CK; Kim, DD
Citation
International journal of pharmaceutics, 395(1-2):309-316, 2010
Journal Title
International journal of pharmaceutics
ISSN
0378-51731873-3476
Abstract
To enhance the solubility and bioavailability of poorly absorbable fexofenadine, microemulsion system composed of oil, surfactant and co-surfactant was developed for intranasal delivery. Phase behavior, particle size, viscosity and solubilization capacity of the microemulsion system were characterized. Histopathology and in vivo nasal absorption of the optimized microemulsion formulations were also investigated in rats. A single isotropic region was found in the pseudo-ternary phase diagrams developed at various ratios with Lauroglycol 90 as oil, Labrasol as surfactant and Plurol Oleique CC49 or its mixture with PEG-400 (1:1) as cosurfactant. An increase in the microemulsion region in pseudo-ternary phase systems was observed with increased surfactant concentration. The optimized microemulsion formulations showed higher solubulization of fexofenadine, i.e., F1 (22.64 mg/mL) and F2 (22.98 mg/mL), compared to its intrinsic water solubility (1.51 mg/mL). Nasal absorption of fexofenadine from these microemulsions was found to be fairly rapid. Tmax was observed within 5 min after intranasal administration at 1.0 mg/kg dose, and the absolute bioavailability (0-4 h) was about 68% compared to the intravenous administration in rats. Our results suggested that these microemulsion formulations could be used as an effective intranasal dosage form for the rapid-onset delivery of fexofenadine.
MeSH terms
Administration, IntranasalAdministration, OralAnimalsBiological AvailabilityChemistry, PharmaceuticalDrug CompoundingEmulsionsGlycols/chemistryHistamine H1 Antagonists, Non-Sedating/*administration &Injections, IntravenousMaleNasal Mucosa/metabolismOils/chemistryOrganic Chemicals/chemistryParticle SizePolyethylene Glycols/chemistryRatsRats, Sprague-DawleySolubilitySurface-Active Agents/chemistryTechnology, Pharmaceutical/methodsTerfenadine/administration & dosage/*analogs &Viscosity
PMID
20635476
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
AJOU Authors
김, 현준김, 유선
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