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Induction of cell growth arrest by atmospheric non-thermal plasma in colorectal cancer cells.

DC Field Value Language
dc.contributor.authorKim, CH-
dc.contributor.authorBahn, JH-
dc.contributor.authorLee, SH-
dc.contributor.authorKim, GY-
dc.contributor.authorJun, SI-
dc.contributor.authorLee, K-
dc.contributor.authorBaek, SJ-
dc.date.accessioned2011-06-08T06:24:46Z-
dc.date.available2011-06-08T06:24:46Z-
dc.date.issued2010-
dc.identifier.issn0168-1656-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2858-
dc.description.abstractPlasma is generated by ionizing neutral gas molecules, resulting in a mixture of energy particles, including electrons and ions. Recent progress in the understanding of non-thermal atmospheric plasma has led to applications in biomedicine. However, the exact molecular mechanisms involved in plasma-induced cell growth arrest are unclear. In this study, we investigated the feasibility of non-thermal atmospheric plasma treatment for cancer therapy and examined the mechanism by which plasma induces anti-proliferative properties and cell death in human colorectal cancer cells. Non-thermal atmospheric plasma induced cell growth arrest and induced apoptosis. In addition, plasma reduced cell migration and invasion activities. As a result, we found that plasma treatment to the cells increases β-catenin phosphorylation, suggesting that β-catenin degradation plays a role at least in part in plasma-induced anti-proliferative activity. Therefore, non-thermal atmospheric plasma constitutes a new biologic tool with the potential for therapeutic applications that modulate cell signaling and function.-
dc.language.isoen-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Movement/physiology-
dc.subject.MESH*Cell Proliferation-
dc.subject.MESHColorectal Neoplasms/*therapy-
dc.subject.MESHFlow Cytometry-
dc.subject.MESHHumans-
dc.subject.MESHIn Situ Nick-End Labeling-
dc.subject.MESHIndoles-
dc.subject.MESHPhosphorylation-
dc.subject.MESHPlasma Gases/*therapeutic use-
dc.subject.MESHSignal Transduction/*physiology-
dc.subject.MESHbeta Catenin/metabolism-
dc.titleInduction of cell growth arrest by atmospheric non-thermal plasma in colorectal cancer cells.-
dc.typeArticle-
dc.identifier.pmid20959125-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0168-1656(10)01917-6-
dc.contributor.affiliatedAuthor김, 철호-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.jbiotec.2010.10.003-
dc.citation.titleJournal of biotechnology-
dc.citation.volume150-
dc.citation.number4-
dc.citation.date2010-
dc.citation.startPage530-
dc.citation.endPage538-
dc.identifier.bibliographicCitationJournal of biotechnology, 150(4):530-538, 2010-
dc.identifier.eissn1873-4863-
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Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
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