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Optimal bolus dose of alfentanil for successful tracheal intubation during sevoflurane induction with and without nitrous oxide in children.

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dc.contributor.authorKwak, HJ-
dc.contributor.authorKim, JY-
dc.contributor.authorMin, SK-
dc.contributor.authorKim, JS-
dc.date.accessioned2011-06-09-
dc.date.available2011-06-09-
dc.date.issued2010-
dc.identifier.issn0007-0912-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2869-
dc.description.abstractBACKGROUND: The goals of this study were to determine the effective bolus dose of alfentanil required for successful tracheal intubation during inhalation induction using sevoflurane 5% without neuromuscular block in children, and whether nitrous oxide reduces these doses.



METHODS: Fifty paediatric patients, aged 3-10 yr, were randomly assigned to one of the two groups. Subjects received either sevoflurane 5% in oxygen 100% (O(2) group, n=25) or sevoflurane 5% in oxygen 40% and nitrous oxide 60% (N(2)O group, n=25) through a face mask. One minute after inhalation induction, a predetermined dose of alfentanil was injected over 15 s. The alfentanil dose was determined using Dixon's up-and-down method, starting from alfentanil 14 microg kg(-1). The trachea was intubated 3 min after inducing anaesthesia.



RESULTS: The ED(50) [95% confidence interval (CI)] of alfentanil for successful tracheal intubation was 11.5 (9.9-13.1) and 8.6 (7.4-9.8) microg kg(-1) in the O(2) and N(2)O groups, respectively. The ED(50) of the N(2)O group was significantly lower than that of the O(2) group (P=0.0146)(.) From isotonic regression, 50% effective dose (ED(50)) (95% CI) of alfentanil in the O(2) and N(2)O groups was 11.4 (9.9-13.0) and 6.5 (5.0-8.1) microg kg(-1), respectively.



CONCLUSIONS: The effective bolus dose of alfentanil for successful tracheal intubation was 11.5 microg kg(-1) in 50% of children during inhalation induction using sevoflurane 5% without neuromuscular blocking agent. Addition of nitrous oxide 60% in oxygen reduced the effective alfentanil dose by 25%.
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dc.language.isoen-
dc.subject.MESHAlfentanil-
dc.subject.MESHAnalgesics, Opioid-
dc.subject.MESHAnesthetics, Combined-
dc.subject.MESHAnesthetics, Inhalation-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHFemale-
dc.subject.MESHHemodynamics-
dc.subject.MESHHumans-
dc.subject.MESHIntubation, Intratracheal-
dc.subject.MESHMale-
dc.subject.MESHMethyl Ethers-
dc.subject.MESHNitrous Oxide-
dc.titleOptimal bolus dose of alfentanil for successful tracheal intubation during sevoflurane induction with and without nitrous oxide in children.-
dc.typeArticle-
dc.identifier.pmid20335182-
dc.identifier.urlhttp://bja.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=20335182-
dc.contributor.affiliatedAuthor김, 종엽-
dc.contributor.affiliatedAuthor민, 상기-
dc.contributor.affiliatedAuthor김, 진수-
dc.type.localJournal Papers-
dc.identifier.doi10.1093/bja/aeq055-
dc.citation.titleBritish journal of anaesthesia-
dc.citation.volume104-
dc.citation.number5-
dc.citation.date2010-
dc.citation.startPage628-
dc.citation.endPage632-
dc.identifier.bibliographicCitationBritish journal of anaesthesia, 104(5). : 628-632, 2010-
dc.identifier.eissn1471-6771-
dc.relation.journalidJ000070912-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
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