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Chemical ablation of the gallbladder with acetic acid.

Authors
Lee, JH; Won, JH; Bae, JI; Kim, JH; Lee, HS; Jung, SM
Citation
Journal of vascular and interventional radiology : JVIR, 20(11):1471-1476, 2009
Journal Title
Journal of vascular and interventional radiology : JVIR
ISSN
1051-04431535-7732
Abstract
PURPOSE: Chemical ablation of the gallbladder may be a useful alternative to surgery for inoperable disease. The purpose of this study was to investigate the feasibility of chemical ablation of the gallbladder with acetic acid in a canine model.



MATERIALS AND METHODS: Five beagle dogs underwent percutaneous transhepatic cholecystostomy. Percutaneous occlusion of the cystic duct was performed with use of n-butyl cyanoacrylate (NBCA) and coils. After confirmation of occlusion of the cystic duct, sclerotherapy of the gallbladder was performed with 4-7 mL of 50% acetic acid through the drainage catheter. Acetic acid was retained for 20 minutes with intermittent position change. The drainage catheter was removed immediately after sclerotherapy. The dogs were euthanized 8 weeks after the procedure. The gallbladders and adjacent organs were evaluated grossly as well as microscopically.



RESULTS: All dogs survived without serious complications during the experimental period. Sclerotherapy was technically successful in all dogs. Gross specimens of the gallbladder showed shrinkage and fibrotic change without retention of any bile, mucus, or pus. Histologic examinations from the body and fundus of the gallbladder demonstrated complete ablation of the mucosa. However, the neck region of the gallbladder near the cystic duct, where NBCA and coils for cystic duct occlusion were located, had focal areas of remnant or regenerating mucosa.



CONCLUSIONS: Chemical ablation of the gallbladder with 50% acetic acid was effective and safe. Complete ablation was achieved in the majority of gallbladder mucosa except for a small portion located in the gallbladder neck.
MeSH terms
Ablation Techniques/methods*Acetic Acid/administration & dosage*AnimalsDogsGallbladder/drug effects*Gallbladder/pathology*Sclerosing Solutions/administration & dosage*Sclerotherapy/methods*
DOI
10.1016/j.jvir.2009.07.028
PMID
19766017
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
원, 제환배, 재익김, 장희
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