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Prognosis for craniofacial fibrous dysplasia after incomplete resection: age and serum alkaline phosphatase.

Authors
Park, BY; Cheon, YW; Kim, YO; Pae, NS; Lee, WJ
Citation
International journal of oral and maxillofacial surgery, 39(3):221-226, 2010
Journal Title
International journal of oral and maxillofacial surgery
ISSN
0901-50271399-0020
Abstract
Complete resection is usually impossible for fibrous dysplasia (FD) involving the cranial base. Incomplete resection could be followed by regrowth of FD, but there is no method for indicating disease progress. Serum alkaline phosphatase (ALP) is significantly high in patients with FD. The authors investigate the relationship between ALP, progress of FD, and age at surgery. 18 patients with craniofacial FD were separated into 3 groups: Group A, complete resection; Group B, incomplete resection followed by regrowth of FD; and Group C, incomplete resection but no regrowth of FD. Medical records and CT scans were reviewed retrospectively. ALP levels were obtained preoperatively, postoperatively and every year during follow-up. The relation between ALP and regrowth and that between age at surgery and regrowth were investigated. There was no recurrence in Group A (n=4). Regrowth in Group B (n=7) was preceded by an abrupt increase in ALP. In Group C (n=7), no regrowth was observed and ALP was maintained within the normal range. 6 patients (85%) in Group B and 2 (28%) in Group C were under 17 years old. The results revealed that the level of postoperative serum ALP could be a reliable marker for predicting the progress of craniofacial FD.
MeSH terms
AdolescentAdultAge FactorsAlkaline Phosphatase/blood*Biological Markers/bloodBone TransplantationChildDisease ProgressionFacial Bones/surgery*FemaleFibrous Dysplasia, Monostotic/bloodFibrous Dysplasia, Monostotic/surgeryFibrous Dysplasia, Polyostotic/bloodFibrous Dysplasia, Polyostotic/surgery*Follow-Up StudiesForecastingHumansLongitudinal StudiesMaleMiddle AgedOsteotomy/methodsPrognosisRecurrenceRemission InductionRetrospective StudiesSkull Base/surgery*Tomography, X-Ray ComputedTreatment OutcomeYoung Adult
DOI
10.1016/j.ijom.2009.12.008
PMID
20083386
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Plastic & Reconstructive Surgery
AJOU Authors
배, 남석
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