Toxicity Evaluation of Rat Muscle-Derived Stem Cells by Galantamine.
Kim, ES; Kim, GH; Kang, ML; Kang, YM; Kang, KN; Lee, JH; Min, BH; Kim, JH; Kim, MS
Tissue engineering and regenerative medicine, 7(3):362-366, 2010
Tissue engineering and regenerative medicine
Muscle-derived stem cells (MDSCs) can be differentiated into various types of cells. In this research, toxicity evaluation of MDSCs with galantamine (Gal) used to treat neurological diseases was first conducted for rat MDSCs. MDSCs treated with Gal showed that cytoplasm condensed around the nucleus and stretched out the dendrites from the nucleus. Compared to the control group and the positive control group, it is confirmed that Gal possesses toxicity. In the toxicity evaluation of cells in different chemical concentrations, it was found that the group treated with Gal showed relatively low toxicity after I day and high those after 4 days, but as time went by, it was confirmed that the proliferation of cells was well accomplished.
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