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Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia.

Authors
Park, HS; Lee, BK; Park, S; Kim, SU; Lee, SH; Baik, EJ; Lee, S; Yi, KY; Yoo, SE; Moon, CH; Jung, YS
Citation
Brain research, 1061(1):67-71, 2005
Journal Title
Brain research
ISSN
0006-89931872-6240
Abstract
We investigated the effects of an Na(+)/H(+) exchanger inhibitor, sabiporide, on excitotoxicity in cultured neuronal cells and in vivo. Sabiporide attenuated glutamate- or NMDA (N-methyl-d-aspartic acid)-induced neuronal cell death. Sabiporide also reduced glutamate or NMDA-induced increase in [Ca(2+)](i). In in vivo brain ischemia model, sabiporide produced protective effects, decreasing the infarct size and edema volume. Our results suggest that sabiporide elicits neuroprotective effect both in vitro and in vivo.
MeSH terms
AnimalsBrain Infarction/etiologyBrain Infarction/pathologyBrain Infarction/prevention & controlBrain Ischemia/chemically inducedBrain Ischemia/drug therapyBrain Ischemia/pathology*Calcium/metabolismCell Death/drug effectsCells, CulturedCerebral Cortex/pathologyDisease Models, AnimalDose-Response Relationship, DrugDrug InteractionsExtracellular Space/drug effectsGlutamic Acid/adverse effectsGuanidines/pharmacology*Guanidines/therapeutic useMiceN-Methylaspartate/adverse effectsNeurons/drug effects*Neurons/pathologyReperfusion/methodsSodium-Hydrogen Antiporter/antagonists & inhibitors*Tetrazolium Salts/diagnostic useThiazoles/diagnostic use
DOI
10.1016/j.brainres.2005.09.002
PMID
16225853
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
김, 승업이, 수환백, 은주문, 창현정, 이숙
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