Cited 0 times in Scipus Cited Count

Caspase-3-mediated cleavage of PHF-1 tau during apoptosis irrespective of excitotoxicity and oxidative stress: an implication to Alzheimer's disease.

DC Field Value Language
dc.contributor.authorKang, HJ-
dc.contributor.authorYoon, WJ-
dc.contributor.authorMoon, GJ-
dc.contributor.authorKim, DY-
dc.contributor.authorSohn, S-
dc.contributor.authorKwon, HJ-
dc.contributor.authorGwag, BJ-
dc.date.accessioned2011-06-15T06:54:08Z-
dc.date.available2011-06-15T06:54:08Z-
dc.date.issued2005-
dc.identifier.issn0969-9961-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/2938-
dc.description.abstractExcitotoxicity, oxidative stress, and apoptosis have been recognized as routes to neuronal death in various neurological diseases. We examined the possibility that PHF-1 tau, a substrate for various proteases, would be selectively cleaved depending upon routes of neuronal death. Cleavage form of PHF-1 tau was not observed in cortical cell cultures exposed to excitotoxins or oxidative stress that cause neuronal cell necrosis. PHF-1 tau was cleaved within 8 h following exposure of cortical cell cultures to apoptosis-inducing agents. This cleavage was blocked by inclusion of zDEVD-fmk, an inhibitor of caspase-3, and accompanied by activation of caspase-3. Levels and cleavage of PHF-1 tau were markedly increased in AD brain compared with control. Moreover, PHF-1 tau and active caspase-3 were colocalized mostly in tangle-bearing neurons. The current findings suggest that PHF-1 tau is cleaved by caspase-3 during apoptosis and neurodegenerative process in AD.-
dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlzheimer Disease-
dc.subject.MESHAnimals-
dc.subject.MESHAntibodies, Monoclonal-
dc.subject.MESHApoptosis-
dc.subject.MESHCaspase 3-
dc.subject.MESHCaspases-
dc.subject.MESHCell Proliferation-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCerebral Cortex-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHOxidative Stress-
dc.subject.MESHSubstrate Specificity-
dc.subject.MESHtau Proteins-
dc.titleCaspase-3-mediated cleavage of PHF-1 tau during apoptosis irrespective of excitotoxicity and oxidative stress: an implication to Alzheimer's disease.-
dc.typeArticle-
dc.identifier.pmid15755671-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0969-9961(04)00292-X-
dc.contributor.affiliatedAuthor강, 효정-
dc.contributor.affiliatedAuthor손, 성향-
dc.contributor.affiliatedAuthor곽, 병주-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.nbd.2004.12.004-
dc.citation.titleNeurobiology of disease-
dc.citation.volume18-
dc.citation.number3-
dc.citation.date2005-
dc.citation.startPage450-
dc.citation.endPage458-
dc.identifier.bibliographicCitationNeurobiology of disease, 18(3). : 450-458, 2005-
dc.identifier.eissn1095-953X-
dc.relation.journalidJ009699961-
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse